Kzr-616
Kzr-616 is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target proteasome subunit beta type-8, proteasome subunit beta type-5, proteasome subunit beta type-2, and proteasome subunit beta type-9.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Mock data
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dermatomyositis | D003882 | EFO_0000398 | M33 | — | 2 | — | — | — | 2 |
| Polymyositis | D017285 | EFO_0003063 | M33.2 | — | 2 | — | — | — | 2 |
| Lupus nephritis | D008181 | EFO_0005761 | 1 | 2 | — | — | — | 2 | |
| Thrombocytopenic purpura idiopathic | D016553 | EFO_0007160 | D69.3 | — | 1 | — | — | — | 1 |
| Hemolytic anemia autoimmune | D000744 | EFO_1001264 | D59.10 | — | 1 | — | — | — | 1 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | 1 | — | — | — | 1 |
| Autoimmune hepatitis | D019693 | K75.4 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | KZR-616 |
| INN | zetomipzomib |
| Description | Kzr-616 is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target proteasome subunit beta type-8, proteasome subunit beta type-5, proteasome subunit beta type-2, and proteasome subunit beta type-9. |
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc([C@@H](O)[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](CC2=CCCC2)C(=O)[C@@]2(C)CO2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 1629677-75-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297468 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | O4BT6C02M2 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PSMB8
PSMB8
PSMB5
PSMB5
PSMB2
PSMB2
PSMB9
PSMB9
Organism
Homo sapiens
Gene name
PSMB8
Gene synonyms
LMP7, PSMB5i, RING10, Y2
NCBI Gene ID
Protein name
proteasome subunit beta type-8
Protein synonyms
Low molecular mass protein 7, low molecular weight protein 7, Macropain subunit C13, Multicatalytic endopeptidase complex subunit C13, protease component C13, proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7), proteasome catalytic subunit 3i, Proteasome component C13, proteasome subunit beta 5i, proteasome subunit beta 8, Proteasome subunit beta-5i, proteasome subunit Y2, proteasome-related gene 7, Really interesting new gene 10 protein
Uniprot ID
Mouse ortholog
Psmb8 (16913)
proteasome subunit beta type-8 (Q91VH7)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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