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Vobarilizumab
Vobarilizumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against interleukin-6 receptor subunit beta.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatoid arthritisD001172EFO_0000685M06.924———5
Systemic lupus erythematosusD008180EFO_0002690M32—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVOBARILIZUMAB
INNvobarilizumab
Description
Vobarilizumab (INN; development code ALX0061) is a humanized bispecific nanobody (Llama-derived heavy-chain only (Vhh) antibody) designed for the treatment of inflammatory autoimmune diseases.
Classification
Antibody
Drug classantiviral (arildone derivatives); monoclonal antibodies
Image (chem structure or protein)VOBARILIZUMAB
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB7XL0
CAS-ID1628814-88-9
RxCUI—
ChEMBL IDCHEMBL3833343
ChEBI ID—
PubChem CID—
DrugBankDB14891
UNII ID9OD8ISS64U (ChemIDplus, GSRS)
Target
Agency Approved
IL6ST
IL6ST
Organism
Homo sapiens
Gene name
IL6ST
Gene synonyms
NCBI Gene ID
3572
Protein name
interleukin-6 receptor subunit beta
Protein synonyms
CD130, CD130 antigen, CDw130, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, gp130, oncostatin M receptor, IL-6 receptor subunit beta, IL-6R subunit beta, interleukin receptor beta chain, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha
Uniprot ID
P40189
Mouse ortholog
Il6st (16195)
interleukin-6 receptor subunit beta (Q00560)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 60 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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