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Retinol
Retinol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target nuclear receptor subfamily 2 group C member 2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
spf 30 with retinolExport only2023-02-10
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11C: Vitamin a and d, incl. combinations of the two
— A11CA: Vitamin a, plain
— A11CA01: Retinol (vit a)
D: Dermatologicals
— D10: Anti-acne preparations
— D10A: Anti-acne preparations for topical use
— D10AD: Retinoids for topical use in acne
— D10AD02: Retinol
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AX: Other nasal preparations in atc
— R01AX02: Retinol
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01X: Other ophthalmologicals in atc
— S01XA: Other ophthalmologicals in atc
— S01XA02: Retinol
HCPCS
No data
Clinical
Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRETINOL
INNretinol
Description
Retinol is a retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraen-1-ol substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified). It has a role as a human metabolite. It is a primary allylic alcohol and a retinoid.
Classification
Small molecule
Drug classvitamin
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC1=C(/C=C/C(C)=C/C=C/C(C)=C/CO)C(C)(C)CCC1
Identifiers
PDB—
CAS-ID11103-57-4
RxCUI—
ChEMBL IDCHEMBL986
ChEBI ID17336
PubChem CID1071
DrugBankDB00162
UNII IDG2SH0XKK91 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NR2C2
NR2C2
Organism
Homo sapiens
Gene name
NR2C2
Gene synonyms
TAK1, TR4
NCBI Gene ID
7182
Protein name
nuclear receptor subfamily 2 group C member 2
Protein synonyms
Nuclear hormone receptor TR4, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, orphan receptor TR4, testicular nuclear receptor 4, Testicular receptor 4
Uniprot ID
P55092
Mouse ortholog
Nr2c2 (22026)
nuclear receptor subfamily 2 group C member 2 (P49117)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 33,805 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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13 adverse events reported
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