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Vilazodone
Viibryd (vilazodone) is a small molecule pharmaceutical. Vilazodone was first approved as Viibryd on 2011-01-21. It is used to treat major depressive disorder in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 1A and sodium-dependent serotonin transporter. In addition, it is known to target D(3) dopamine receptor, D(2) dopamine receptor, histamine H1 receptor, and 5-hydroxytryptamine receptor 4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
Viibryd (generic drugs available since 2019-09-30)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Vilazodone hydrochloride
Tradename
Company
Number
Date
Products
VIIBRYDAbbVieN-022567 RX2011-01-21
3 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
viibrydNew Drug Application2021-09-20
vilazodone hydrochlorideANDA2023-03-27
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
major depressive disorderEFO_0003761D003865F22
Agency Specific
FDA
EMA
Expiration
Code
VILAZODONE HYDROCHLORIDE, VIIBRYD, ABBVIE
2023-07-31PED
2023-01-31M-254
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AX: Other antidepressants in atc
— N06AX24: Vilazodone
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B20——1——1
Herpes simplexD006561B00——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVILAZODONE
INNvilazodone
Description
Vilazodone is a 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder. It has a role as an antidepressant, a serotonergic agonist and a serotonin uptake inhibitor. It is a member of indoles, a nitrile, a N-arylpiperazine, a N-alkylpiperazine, a member of 1-benzofurans and a monocarboxylic acid amide. It is a conjugate base of a vilazodone(1+).
Classification
Small molecule
Drug classSerotonin modulator
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5oc(C(N)=O)cc5c4)CC3)c2c1
Identifiers
PDB—
CAS-ID163521-12-8
RxCUI1086769
ChEMBL IDCHEMBL439849
ChEBI ID70707
PubChem CID6918314
DrugBankDB06684
UNII IDS239O2OOV3 (ChemIDplus, GSRS)
Target
Agency Approved
HTR1A
HTR1A
SLC6A4
SLC6A4
Organism
Homo sapiens
Gene name
HTR1A
Gene synonyms
ADRB2RL1, ADRBRL1
NCBI Gene ID
3350
Protein name
5-hydroxytryptamine receptor 1A
Protein synonyms
5-HT1a receptor, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, G-21, guanine nucleotide-binding regulatory protein-coupled receptor, Serotonin receptor 1A
Uniprot ID
Q6LAE7
Mouse ortholog
Htr1a (15550)
5-hydroxytryptamine receptor 1A (Q8BGS4)
Alternate
DRD3
DRD3
DRD2
DRD2
HRH1
HRH1
HTR4
HTR4
Organism
Homo sapiens
Gene name
DRD3
Gene synonyms
NCBI Gene ID
1814
Protein name
D(3) dopamine receptor
Protein synonyms
Dopamine D3 receptor, essential tremor 1
Uniprot ID
Q4VBM8
Mouse ortholog
Drd3 (13490)
D(3) dopamine receptor (P30728)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 802 documents
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Safety
Black-box Warning
Black-box warning for: Viibryd, Vilazodone hydrochloride
Adverse Events
Top Adverse Reactions
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47 adverse events reported
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