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Verosudil
Verosudil is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target rho-associated protein kinase 1 and rho-associated protein kinase 2.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ocular hypertensionD009798EFO_1001069H40.0—6———6
Open-angle glaucomaD005902EFO_0004190H40.1—4———4
GlaucomaD005901EFO_0000516H40—4———4
Exfoliation syndromeD017889EFO_0004235—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameVEROSUDIL
INNverosudil
Description
Verosudil (AR-12286) is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase, and has been investigated for the treatment of glaucoma.
Classification
Small molecule
Drug classvasodilators (undefined group): Rho protein kinase (ROCK) inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)C(C(=O)Nc1ccc2c(=O)[nH]ccc2c1)c1ccsc1
Identifiers
PDB—
CAS-ID1414854-42-4
RxCUI—
ChEMBL IDCHEMBL3545065
ChEBI ID—
PubChem CID66906051
DrugBank—
UNII IDMAF34143WM (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ROCK1
ROCK1
ROCK2
ROCK2
Organism
Homo sapiens
Gene name
ROCK1
Gene synonyms
NCBI Gene ID
6093
Protein name
rho-associated protein kinase 1
Protein synonyms
p160 ROCK-1, p160ROCK, Renal carcinoma antigen NY-REN-35, Rho-associated, coiled-coil-containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, ROCK-I
Uniprot ID
Q59GZ4
Mouse ortholog
Rock1 (19877)
rho-associated protein kinase 1 (Q8C7H0)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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