Vecuronium
Norcuron (vecuronium) is a small molecule pharmaceutical. Vecuronium was first approved as Norcuron on 1984-04-30.
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Abbreviated New Drug Application (ANDA)
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Vecuronium bromide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NORCURON | Organon | N-018776 DISCN | 1984-04-30 | 2 products, RLD |
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Brand Name | Status | Last Update |
|---|---|---|
| vecuronium bromide | ANDA | 2023-01-18 |
Indications
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Agency Specific
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Clinical
Clinical Trials
84 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Septic shock | D012772 | A48.3 | — | 3 | 3 | 2 | 5 | 11 | |
| Heart arrest | D006323 | EFO_0009492 | I46 | 2 | 2 | 4 | 1 | 1 | 9 |
| Shock | D012769 | R57.1 | — | 1 | 2 | 1 | — | 3 | |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | 1 | 1 | 2 |
| Endotoxemia | D019446 | — | — | — | 1 | — | 1 | ||
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | 1 | — | 1 |
| Surgical blood loss | D016063 | — | — | — | 1 | — | 1 | ||
| General anesthesia | D000768 | — | — | — | 1 | — | 1 | ||
| Artificial respiration | D012121 | — | — | — | 1 | — | 1 | ||
| Pulmonary arterial hypertension | D000081029 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Autism spectrum disorder | D000067877 | F84.0 | 1 | 2 | 1 | — | — | 3 | |
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | — | 1 | 1 | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 1 | — | — | 1 |
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | — | 1 | 1 | — | — | 1 |
| Pleural effusion | D010996 | J90 | — | 1 | 1 | — | — | 1 | |
| Sepsis | D018805 | A41.9 | — | 1 | 1 | — | — | 1 | |
| Hypovolemia | D020896 | HP_0011106 | E86 | — | 1 | 1 | — | — | 1 |
| Hemorrhagic shock | D012771 | — | 1 | 1 | — | — | 1 | ||
| Spontaneous abortion | D000022 | EFO_1001255 | O00.1 | — | — | 1 | — | — | 1 |
| Vasoplegia | D056987 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Traumatic shock | D012774 | T79.4 | 1 | 1 | — | — | — | 2 | |
| Hypertension | D006973 | EFO_0000537 | I10 | — | 1 | — | — | 1 | 2 |
| Acute lung injury | D055371 | EFO_0004610 | — | 1 | — | — | — | 1 | |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | 1 | — | — | — | 1 |
| Acute pain | D059787 | R52 | 1 | 1 | — | — | — | 1 | |
| Out-of-hospital cardiac arrest | D058687 | — | 1 | — | — | — | 1 | ||
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | — | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 1 | — | — | — | 1 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | 1 | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myoma | D009214 | D21 | — | — | — | — | 2 | 2 | |
| Rotator cuff tear arthropathy | D000070656 | — | — | — | — | 1 | 1 | ||
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 1 | 1 |
| Placenta previa | D010923 | EFO_0007442 | O44 | — | — | — | — | 1 | 1 |
| Hyponatremia | D007010 | HP_0002902 | E87.1 | — | — | — | — | 1 | 1 |
| Hypernatremia | D006955 | HP_0003228 | E87.0 | — | — | — | — | 1 | 1 |
| Liver failure | D017093 | HP_0001399 | K72.9 | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Induced abortion | D000028 | — | — | — | — | 1 | 1 | ||
| Traumatic brain injuries | D000070642 | S06 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | VECURONIUM |
| INN | vecuronium bromide |
| Description | Vecuronium bromide is the organic bromide salt of a 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidinino- and 16beta-N-methylpiperidinium substituents. It has a role as a nicotinic antagonist, a neuromuscular agent and a muscle relaxant. It is a quaternary ammonium salt and an organic bromide salt. It contains a vecuronium. It is functionally related to a 5alpha-androstane. |
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives: neuromuscular blocking agents; quaternary ammonium derivatives: neuromuscular blocking agents |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@H](CC[C@@]4(C)[C@H]3C[C@H]([N+]3(C)CCCCC3)[C@@H]4OC(C)=O)[C@@]2(C)C[C@@H]1N1CCCCC1 |
Identifiers
| PDB | — |
| CAS-ID | 50700-72-6 |
| RxCUI | 11153 |
| ChEMBL ID | CHEMBL1201219 |
| ChEBI ID | 9939 |
| PubChem CID | 39764 |
| DrugBank | DB01339 |
| UNII ID | 7E4PHP5N1D (ChemIDplus, GSRS) |
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Safety
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161 adverse events reported
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