Tryptophan
Tryptophan is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against probable G-protein coupled receptor 139 and angiotensin-converting enzyme. In addition, it is known to target extracellular calcium-sensing receptor, proton-coupled amino acid transporter 1, proton-coupled amino acid transporter 2, hydroxycarboxylic acid receptor 3, sodium- and chloride-dependent neutral and basic amino acid transporter B(0+), receptor-interacting serine/threonine-protein kinase 1, and indoleamine 2,3-dioxygenase 1.
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Commercial
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| depression | — | D003863 | F33.9 |
| pain | EFO_0003843 | D010146 | R52 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
39 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | 1 | — | 1 | |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | 2 | 1 | — | — | 2 |
| Delirium | D003693 | R41.0 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 1 | — | — | 2 | 5 |
| Neoplasms | D009369 | C80 | 4 | 1 | — | — | — | 4 | |
| Psychotic disorders | D011618 | F20.81 | 1 | 1 | — | — | — | 1 | |
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | — | 1 | — | — | — | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | — | 1 |
| Male breast neoplasms | D018567 | 1 | 1 | — | — | — | 1 | ||
| Cocaine-related disorders | D019970 | F14 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Affect | D000339 | 1 | — | — | — | 1 | 2 | ||
| Social behavior | D012919 | STY/T054 | 2 | — | — | — | — | 2 | |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Lung neoplasms | D008175 | C34.90 | 1 | — | — | — | — | 1 | |
| Melanoma | D008545 | 1 | — | — | — | — | 1 | ||
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Rectal neoplasms | D012004 | 1 | — | — | — | — | 1 | ||
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | — | — | 4 | 4 | ||
| Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | — | — | — | — | 2 | 2 |
| Sleep | D012890 | GO_0030431 | — | — | — | — | 1 | 1 | |
| Psychological burnout | D000077062 | Z73.0 | — | — | — | — | 1 | 1 | |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | — | — | — | 1 | 1 |
| Chronic renal insufficiency | D051436 | N18 | — | — | — | — | 1 | 1 | |
| Coronary artery disease | D003324 | I25.1 | — | — | — | — | 1 | 1 | |
| Sleepiness | D000077260 | R40.0 | — | — | — | — | 1 | 1 | |
| Diet therapy | D004035 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TRYPTOPHAN |
| INN | tryptophan |
| Description | L-tryptophan is the L-enantiomer of tryptophan. It has a role as an antidepressant, a nutraceutical, a micronutrient, a plant metabolite, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is an erythrose 4-phosphate/phosphoenolpyruvate family amino acid, a proteinogenic amino acid, a tryptophan and a L-alpha-amino acid. It is a conjugate base of a L-tryptophanium. It is a conjugate acid of a L-tryptophanate. It is an enantiomer of a D-tryptophan. It is a tautomer of a L-tryptophan zwitterion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O |
Identifiers
| PDB | 5K5S |
| CAS-ID | 73-22-3 |
| RxCUI | 10898 |
| ChEMBL ID | CHEMBL54976 |
| ChEBI ID | 16828 |
| PubChem CID | 6305 |
| DrugBank | DB00150 |
| UNII ID | 8DUH1N11BX (ChemIDplus, GSRS) |
Target
Agency Approved
GPR139
GPR139
ACE
ACE
Organism
Homo sapiens
Gene name
GPR139
Gene synonyms
GPRG1, PGR3
NCBI Gene ID
Protein name
probable G-protein coupled receptor 139
Protein synonyms
G protein-coupled receptor PGR3, G(q)-coupled orphan receptor GPRg1, G-protein-coupled receptor PGR3
Uniprot ID
Mouse ortholog
Gpr139 (209776)
probable G-protein coupled receptor 139 (Q80UC8)
Alternate
CASR
CASR
SLC36A1
SLC36A1
SLC36A2
SLC36A2
HCAR3
HCAR3
SLC6A14
SLC6A14
RIPK1
RIPK1
IDO1
IDO1
Organism
Homo sapiens
Gene name
CASR
Gene synonyms
GPRC2A, PCAR1
NCBI Gene ID
Protein name
extracellular calcium-sensing receptor
Protein synonyms
parathyroid Ca(2+)-sensing receptor 1, Parathyroid cell calcium-sensing receptor 1, PCaR1
Uniprot ID
Mouse ortholog
Casr (12374)
extracellular calcium-sensing receptor (Q9R1Y2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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386 adverse events reported
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