Trovan, Turvel iv(trovafloxacin)
Trovan, Trovan/zithromax Compliance, Turvel (trovafloxacin) is a small molecule pharmaceutical. Trovafloxacin was first approved as Trovan on 1997-12-18. It is used to treat bacterial pneumonia, bacteroides infections, bronchitis, chlamydia infections, and escherichia coli infections amongst others in the USA. It has been approved in Europe to treat bacterial infections.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| respiratory tract diseases | D012140 |
| otorhinolaryngologic diseases | D010038 |
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| bacterial pneumonia | EFO_1001272 | D018410 | J15.9 |
| bacteroides infections | EFO_1000832 | D001442 | — |
| bronchitis | — | D001991 | J40 |
| chlamydia infections | EFO_0007205 | D002690 | A74.9 |
| escherichia coli infections | EFO_1001318 | D004927 | B96.20 |
| gonorrhea | DOID_7551 | D006069 | A54 |
| haemophilus infections | EFO_1001127 | D006192 | — |
| klebsiella infections | EFO_1001353 | D007710 | — |
| pseudomonas infections | EFO_0001076 | D011552 | — |
| sinusitis | EFO_0007486 | D012852 | J32 |
Show 3 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
28 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | — | — | 1 | 5 | 3 | 9 |
| Urge urinary incontinence | D053202 | EFO_0006865 | N39.41 | — | — | 1 | 1 | — | 2 |
| Urinary incontinence | D014549 | HP_0000020 | R32 | 1 | — | — | 1 | — | 2 |
| Pharmacokinetics | D010599 | 1 | — | — | 1 | — | 2 | ||
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | 1 | — | 1 | |
| Cognition | D003071 | EFO_0003925 | — | — | — | 1 | — | 1 | |
| Mental competency | D016743 | — | — | — | 1 | — | 1 | ||
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | 1 | 7 | — | — | 9 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 | ||
| Drug interactions | D004347 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ureteral obstruction | D014517 | HP_0006000 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | TROVAFLOXACIN |
| INN | trovafloxacin |
| Description | Trovafloxacin (sold as Trovan by Pfizer and Turvel by Laboratorios Almirall) is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was withdrawn from the market due to the risk of hepatotoxicity. It had better Gram-positive bacterial coverage but less Gram-negative coverage than the previous fluoroquinolones.
|
| Classification | Small molecule |
| Drug class | antibacterials (quinolone derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | N[C@H]1[C@@H]2CN(c3nc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3F)C[C@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 147059-72-1 |
| RxCUI | 115552 |
| ChEMBL ID | CHEMBL428 |
| ChEBI ID | 9763 |
| PubChem CID | 11464175 |
| DrugBank | DB00685 |
| UNII ID | 9F388J00UK (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 1,945 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
1,374 adverse events reported
View more details
Premium feature
Learn more about premium features at pharmakb.com
Learn more