Skip to content
Trimethoprim
Bactrim, Polytrim, Primsol, Proloprim, Septra, Sulfatrim, Trimpex (trimethoprim) is a small molecule pharmaceutical. Trimethoprim was first approved as Septra on 1982-01-01. It is used to treat aids-related opportunistic infections, bacterial eye infections, bacterial infections, bronchitis, and escherichia coli infections amongst others in the USA.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
eye diseasesD005128
urogenital diseasesD000091642
immune system diseasesD007154
Trade Name
FDA
EMA
Combinations
Bactrim, Septra, Sulfatrim (generic drugs available since 1985-06-06, discontinued: Cotrim, Cotrim d.s, Polytrim, Septra grape, Sulfamethoprim, Sulfatrim-ss, Sulmeprim, Trimeth/sulfa, Uroplus, Uroplus ss)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Phenazopyridine hydrochloride
+
Sulfamethoxazole
+
Trimethoprim
Tradename
Company
Number
Date
Products
SULFAMETHOXAZOLE AND TRIMETHOPRIM AND PHENAZOPYRIDINE HYDROCHLORIDEAble LaboratoriesN-021105 DISCN2001-06-26
1 products
Hide discontinued
Polymyxin b sulfate
+
Trimethoprim sulfate
Tradename
Company
Number
Date
Products
POLYTRIMAllerganN-050567 DISCN1988-10-20
1 products, RLD
Hide discontinued
Sulfamethoxazole
+
Trimethoprim
Tradename
Company
Number
Date
Products
SEPTRAMonarch PharmaceuticalsN-017376 RX1982-01-01
1 products
SEPTRA DSMonarch PharmaceuticalsN-017376 RX1982-01-01
1 products
SULFATRIM PEDIATRICPAI PharmaN-018615 RX1983-01-07
1 products
BACTRIMSun Pharmaceutical IndustriesN-017377 RX1982-01-01
1 products, RLD
BACTRIM DSSun Pharmaceutical IndustriesN-017377 RX1982-01-01
1 products, RLD, RS
Show 14 discontinued
Trimethoprim
Tradename
Company
Number
Date
Products
TRIMETHOPRIMDr Reddys LaboratoriesN-018679 RX1982-07-30
1 products, RLD, RS
Show 3 discontinued
Trimethoprim hydrochloride
Tradename
Company
Number
Date
Products
PRIMSOLAllegis PharmaceuticalsN-074374 DISCN1995-06-23
1 products
PRIMSOLAllegis PharmaceuticalsN-074973 DISCN2000-01-24
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
bactrim bactrim dsNew Drug Application2021-04-29
polytrimNew Drug Application2019-05-10
sulfamethoxazole and trimethoprimANDA2023-06-12
sulfatrimNew Drug Application2023-01-27
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
aids-related opportunistic infections—D017088—
bacterial eye infections—D015818—
bacterial infections—D001424A49
bronchitis—D001991J40
escherichia coli infectionsEFO_1001318D004927B96.20
klebsiella infectionsEFO_1001353D007710—
pneumocystis pneumoniaEFO_0007448D011020B59
proteus infectionsEFO_1001130D011512—
staphylococcal infections—D013203A49.01
toxoplasmosisEFO_0007517D014123B58
Show 1 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01E: Sulfonamides and trimethoprim antibacterials for systemic use
— J01EA: Trimethoprim and derivatives, systemic antibacterials
— J01EA01: Trimethoprim
— J01EE: Combinations of sulfonamides and trimethoprim, incl. derivatives
— J01EE01: Sulfamethoxazole and trimethoprim
— J01EE02: Sulfadiazine and trimethoprim
— J01EE03: Sulfametrole and trimethoprim
— J01EE04: Sulfamoxole and trimethoprim
— J01EE05: Sulfadimidine and trimethoprim
— J01EE07: Sulfamerazine and trimethoprim
— J01R: Combinations of antibacterials
— J01RA: Combinations of antibacterials
— J01RA02: Sulfonamides, combinations with other antibacterials (excl. trimethoprim)
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AM: Combinations of drugs for treatment of tuberculosis
— J04AM08: Isoniazid, sulfamethoxazole, trimethoprim and pyridoxine
HCPCS
Code
Description
S0039
Injection, sulfamethoxazole and trimethoprim, 10 ml
Clinical
Clinical Trials
4 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Parkinson diseaseD010300EFO_0002508G201——2—3
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameTRIMETHOPRIM
INNtrimethoprim
Description
Trimethoprim is an aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, a xenobiotic, an environmental contaminant, a drug allergen, an antibacterial drug and a diuretic. It is a member of methoxybenzenes and an aminopyrimidine.
Classification
Small molecule
Drug classantibacterials (trimethoprim type), dihydrofolate reductase (DHFR) inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
Identifiers
PDB—
CAS-ID738-70-5
RxCUI—
ChEMBL IDCHEMBL22
ChEBI ID45924
PubChem CID5578
DrugBankDB00440
UNII IDAN164J8Y0X (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 60,057 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
218 adverse events reported
View more details