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Trazodone
Desyrel, Oleptro, Trialodine (trazodone) is a small molecule pharmaceutical. Trazodone was first approved as Desyrel on 1982-01-01. It is used to treat depressive disorder and sleep initiation and maintenance disorders in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine receptor 2A. In addition, it is known to target 5-hydroxytryptamine receptor 2B.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Trazodone hydrochloride
Tradename
Company
Number
Date
Products
OLEPTROAngelini PharmaN-022411 DISCN2010-02-02
2 products, RLD
DESYRELPragma PharmaceuticalsN-018207 DISCN1982-01-01
4 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
trazodone hydrochlorideANDA2023-06-14
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
depressive disorderEFO_1002014D003866F32.A
sleep initiation and maintenance disorders—D007319F51.01
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Trazodone Hydrochloride, Desyrel, Pragma
81338932029-03-13DS, DP
Trazodone Hydrochloride, Oleptro, Angelini Pharma
78291202027-03-27DPU-796
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AX: Other antidepressants in atc
— N06AX05: Trazodone
HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DepressionD003863F33.9——11—2
Major depressive disorderD003865EFO_0003761F2211—1—2
Bipolar disorderD001714EFO_0000289F30.9———112
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DementiaD003704F03——1——1
Psychophysiologic disordersD011602F45.9——1——1
SchizophreniaD012559EFO_0000692F20——1——1
Anxiety disordersD001008EFO_0006788F41.1——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myelodysplastic syndromesD009190D4621———2
Myeloid leukemia acuteD015470C92.021———2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pure autonomic failureD0549701————1
Orthostatic hypotensionD007024I95.11————1
LeukemiaD007938C951————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Treatment-resistant depressive disorderD061218————11
Drug-related side effects and adverse reactionsD064420T88.7————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTRAZODONE
INNtrazodone
Description
Trazodone is an N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group. It has a role as an antidepressant, a sedative, an adrenergic antagonist, a H1-receptor antagonist, a serotonin uptake inhibitor and an anxiolytic drug. It is a N-alkylpiperazine, a N-arylpiperazine, a triazolopyridine and a member of monochlorobenzenes.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=c1n(CCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12
Identifiers
PDB—
CAS-ID19794-93-5
RxCUI10737
ChEMBL IDCHEMBL621
ChEBI ID9654
PubChem CID5533
DrugBankDB00656
UNII IDYBK48BXK30 (ChemIDplus, GSRS)
Target
Agency Approved
HTR2C
HTR2C
HTR2A
HTR2A
Organism
Homo sapiens
Gene name
HTR2C
Gene synonyms
HTR1C
NCBI Gene ID
3358
Protein name
5-hydroxytryptamine receptor 2C
Protein synonyms
5-HT-1C, 5-HT1C, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine receptor 1C, serotonin 5-HT-1C receptor, serotonin 5-HT-2C receptor, Serotonin receptor 2C
Uniprot ID
Q9NP28
Mouse ortholog
Htr2c (15560)
5-hydroxytryptamine receptor 2C (Q5WRU6)
Alternate
HTR2B
HTR2B
Organism
Homo sapiens
Gene name
HTR2B
Gene synonyms
NCBI Gene ID
3357
Protein name
5-hydroxytryptamine receptor 2B
Protein synonyms
5-HT 2B receptor, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled, 5-hydroxytryptamine 2B receptor, Serotonin receptor 2B
Uniprot ID
Q6P523
Mouse ortholog
Htr2b (15559)
5-hydroxytryptamine receptor 2B (Q9QWS2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,457 documents
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Safety
Black-box Warning
Black-box warning for: Trazodone hydrochloride
Adverse Events
Top Adverse Reactions
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756 adverse events reported
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