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Tonapofylline
Tonapofylline is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target adenosine receptor A2a, adenosine receptor A3, adenosine receptor A2b, and adenosine receptor A1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart failureD006333EFO_0003144I50—21——2
Renal insufficiencyD051437HP_0000083N19—21——2
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatic insufficiencyD0485501————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTONAPOFYLLINE
INNtonapofylline
Description
Tonapofylline is an oxopurine.
Classification
Small molecule
Drug classtheophylline derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCn1c(=O)c2[nH]c(C34CCC(CCC(=O)O)(CC3)CC4)nc2n(CCC)c1=O
Identifiers
PDB—
CAS-ID340021-17-2
RxCUI—
ChEMBL IDCHEMBL414157
ChEBI ID—
PubChem CID—
DrugBankDB12569
UNII ID83VNU4U44T (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADORA2A
ADORA2A
ADORA3
ADORA3
ADORA2B
ADORA2B
ADORA1
ADORA1
Organism
Homo sapiens
Gene name
ADORA2A
Gene synonyms
ADORA2
NCBI Gene ID
135
Protein name
adenosine receptor A2a
Protein synonyms
adenosine receptor subtype A2a
Uniprot ID
P29274
Mouse ortholog
Adora2a (11540)
adenosine receptor A2a (Q60613)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 18 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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