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Tocainide
Tonocard (tocainide) is a small molecule pharmaceutical. Tocainide was first approved as Tonocard on 1984-11-09. It is used to treat cardiac arrhythmias and trigeminal neuralgia in the USA.
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Therapeutic Areas
Therapeutic Area
MeSH
stomatognathic diseasesD009057
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tocainide hydrochloride
Tradename
Company
Number
Date
Products
TONOCARDAstraZenecaN-018257 DISCN1984-11-09
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
cardiac arrhythmiasEFO_0004269D001145I49.9
trigeminal neuralgiaEFO_1001219D014277G50.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C01: Cardiac therapy drugs
C01B: Antiarrhythmics, class i and iii
C01BB: Antiarrhythmics, class ib
C01BB03: Tocainide
HCPCS
No data
Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Low back painD017116HP_0003419M54.5112
ThyroidectomyD01396511
Shoulder painD020069HP_0030834M25.5111
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple sclerosisD009103EFO_0003885G351112
Muscle spasticityD009128HP_00012571112
StrokeD020521EFO_0000712I63.911
Spinal cord injuriesD013119EFO_100191911
Migraine without auraD020326EFO_0005296G43.011
Migraine with auraD020325EFO_0005295G43.111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Sleep initiation and maintenance disordersD007319F51.0111
Chronic painD059350HP_001253211
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients22
NeoplasmsD009369C8011
Cerebral palsyD002547G8011
Traumatic brain injuriesD000070642S0611
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine disordersD008881EFO_0003821G4311
HeadacheD006261HP_0002315R5111
ArthritisD001168EFO_0005856M05-M1411
TendinopathyD052256EFO_1001434M77.911
SynovitisD013585EFO_0008997M67.511
SpasmD013035M62.8311
RadiculopathyD011843M54.111
GoutD006073EFO_0004274M1011
Postoperative painD010149G89.1811
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTOCAINIDE
INNtocainide
Description
Tocainide is a monocarboxylic acid amide in which 2,6-dimethylphenylaniline and isobutyric acid have combined to form the amide bond; used as a local anaesthetic. It has a role as a local anaesthetic, an anti-arrhythmia drug and a sodium channel blocker.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cccc(C)c1NC(=O)C(C)N
Identifiers
PDB
CAS-ID41708-72-9
RxCUI42359
ChEMBL IDCHEMBL1762
ChEBI ID9611
PubChem CID38945
DrugBankDB01056
UNII ID27DXO59SAN (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 406 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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5,737 adverse events reported
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