Thonzonium
Coly-mycin (thonzonium) is a small molecule pharmaceutical. Thonzonium was first approved as Coly-mycin s on 1982-01-01.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Combinations
Coly-mycin
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Colistin sulfate
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Hydrocortisone acetate
+
Neomycin sulfate
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Thonzonium bromide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COLY-MYCIN S | Endo | N-050356 RX | 1982-01-01 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| coly-mycin | New Drug Application | 2018-12-03 |
| cortisporin tc | New Drug Application | 2019-01-15 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
49 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | 2 | 8 | 1 | 1 | 10 |
| Infections | D007239 | EFO_0000544 | — | — | 4 | 1 | 1 | 6 | |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 1 | 1 | 2 | — | 4 |
| Acinetobacter infections | D000151 | EFO_1000792 | — | — | — | 1 | 2 | 3 | |
| Bacterial infections | D001424 | A49 | — | — | 1 | 1 | 1 | 3 | |
| Critical illness | D016638 | 1 | — | — | 1 | — | 2 | ||
| Communicable diseases | D003141 | — | — | 1 | 1 | — | 2 | ||
| Gram-negative bacterial infections | D016905 | — | — | — | 2 | — | 2 | ||
| Cross infection | D003428 | — | — | 1 | 1 | — | 2 | ||
| Colorectal neoplasms | D015179 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | 1 | 2 | — | 1 | 3 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | 2 | — | 1 | 3 |
| Healthy volunteers/patients | — | — | — | 3 | — | — | 3 | ||
| Sepsis | D018805 | A41.9 | — | — | 1 | — | 1 | 2 | |
| Iatrogenic disease | D007049 | — | — | 1 | — | — | 1 | ||
| Drug-related side effects and adverse reactions | D064420 | T88.7 | — | — | 1 | — | — | 1 | |
| Bronchitis | D001991 | J40 | — | — | 1 | — | — | 1 | |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | 1 | — | — | 1 |
| Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | — | — | 1 | — | — | 1 |
| Healthcare-associated pneumonia | D000077299 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pseudomonas aeruginosa | D011550 | NCBITaxon_287 | — | 1 | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | THONZONIUM |
| INN | tonzonium bromide |
| Description | Thonzonium bromide is a monocationic detergent. A solution of it is thus a surfactant and a detergent that promotes tissue contact by dispersion and penetration of the cellular debris and exudate of the containing solution.
|
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives; quaternary ammonium derivatives |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCCCCCCCCCCCCCCC[N+](C)(C)CCN(Cc1ccc(OC)cc1)c1ncccn1 |
Identifiers
| PDB | — |
| CAS-ID | 553-08-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201322 |
| ChEBI ID | — |
| PubChem CID | 11102 |
| DrugBank | — |
| UNII ID | JI2B19CR0R (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 186 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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112 adverse events reported
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