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Thiopental
Pentothal (thiopental) is a small molecule pharmaceutical. Thiopental was first approved as Pentothal on 1982-01-01. It is used to treat intracranial hypertension in the USA. It is known to target potassium voltage-gated channel subfamily C member 4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Thiopental sodium
Tradename
Company
Number
Date
Products
PENTOTHALAbbott BiotherapeuticsN-011679 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
intracranial hypertensionEFO_1000992D019586—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N01: Anesthetics
— N01A: Anesthetics, general
— N01AF: Barbiturates for general anesthesia, plain
— N01AF03: Thiopental
— N05: Psycholeptics
— N05C: Hypnotics and sedatives
— N05CA: Barbiturates, hypnotics and sedatives, plain
— N05CA19: Thiopental
HCPCS
No data
Clinical
Clinical Trials
82 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.0411176136
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938C951920—332
LymphomaD008223C85.9—24——6
Myelodysplastic syndromesD009190D46——6——6
Myeloid leukemia acuteD015470C92.0——5——5
Down syndromeD004314EFO_0001064Q90—13——4
Brain neoplasmsD001932EFO_0003833C71—11——2
Megakaryoblastic leukemia acuteD007947C94.2——2——2
Monocytic leukemia acuteD007948——2——2
Myelomonocytic leukemia acuteD015479C92.5——2——2
Erythroblastic leukemia acuteD004915EFO_1001257C94.0——2——2
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GlioblastomaD005909EFO_0000515—1———1
ThrombocytopeniaD013921HP_0001873D69.6—1———1
Non-hodgkin lymphomaD008228C85.911———1
Langerhans-cell histiocytosisD006646C96.6—1———1
Hodgkin diseaseD006689C81—1———1
NeoplasmsD009369C8011———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTHIOPENTAL
INNthiopental sodium
Description
Sodium thiopental, also known as Sodium Pentothal (a trademark of Abbott Laboratories), thiopental, thiopentone, or Trapanal (also a trademark), is a rapid-onset short-acting barbiturate general anesthetic. It is the thiobarbiturate analog of pentobarbital, and an analog of thiobarbital. Sodium thiopental was a core medicine in the World Health Organization's List of Essential Medicines, but was supplanted by propofol. Despite this, thiopental is listed as an acceptable alternative to propofol, depending on local availability and cost of these agents. It was previously the first of three drugs administered during most lethal injections in the United States, but the US manufacturer Hospira stopped manufacturing the drug in 2011 and the European Union banned the export of the drug for this purpose. Although thiopental abuse carries a dependency risk, its recreational use is rare.
Classification
Small molecule
Drug classBarbiturate
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCC(C)C1(CC)C(=O)NC(=S)NC1=O
Identifiers
PDB—
CAS-ID76-75-5
RxCUI—
ChEMBL IDCHEMBL441
ChEBI ID102166
PubChem CID3000714
DrugBankDB00599
UNII ID49Y44QZL70 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNC4
KCNC4
Organism
Homo sapiens
Gene name
KCNC4
Gene synonyms
C1orf30
NCBI Gene ID
3749
Protein name
potassium voltage-gated channel subfamily C member 4
Protein synonyms
K+ channel subunit, KSHIIIC, potassium channel, voltage gated Shaw related subfamily C, member 4, potassium voltage-gated channel, Shaw-related subfamily, member 4, Voltage-gated potassium channel subunit Kv3.4
Uniprot ID
Q03721
Mouse ortholog
Kcnc4 (99738)
potassium voltage-gated channel subfamily C member 4 (Q8R1C0)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 14,996 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,328 adverse events reported
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