Thiamine
Berocca Pn, Betalin, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vitaped (thiamine) is a small molecule pharmaceutical. Thiamine was first approved as Thiamine hydrochloride on 1982-01-01. It is used to treat alcoholic neuropathy, beriberi, pellagra, thiamine deficiency, and wernicke encephalopathy in the USA. It is known to target thiamine transporter 1 and thiamine transporter 2.
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Commercial
Trade Name
FDA
EMA
Combinations
Infuvite (discontinued: Berocca pn, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alpha-tocopherol acetate
+
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin k
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| INFUVITE ADULT | Sandoz | N-021163 RX | 2000-05-18 | 2 products, RLD, RS |
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| M.V.I. PEDIATRIC | Hospira | N-018920 DISCN | 2000-09-21 | 1 products, RLD |
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin 5'-phosphate sodium
+
Thiamine
+
Vitamin a
+
Vitamin e
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| M.V.I.-12 LYOPHILIZED | Teligent | N-018933 DISCN | 1985-08-08 | 1 products |
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| M.V.I.-12 ADULT | Hospira | N-008809 DISCN | 2004-04-22 | 1 products |
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
+
Vitamin k
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin e
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BEROCCA PN | Roche | N-006071 DISCN | 1985-10-10 | 1 products |
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VITAPED | Hospira | N-020176 DISCN | 1993-12-29 | 1 products |
Hide discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| adult infuvite multiple vitamins | New Drug Application | 2016-10-28 |
| thiamine | ANDA | 2023-05-22 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| alcoholic neuropathy | EFO_1000803 | D020269 | G62.1 |
| beriberi | EFO_1000837 | D001602 | E51.1 |
| pellagra | — | D010383 | — |
| thiamine deficiency | — | D013832 | E51 |
| wernicke encephalopathy | EFO_1001241 | D014899 | E51.2 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J3411 | Injection, thiamine hcl, 100 mg |
Clinical
Clinical Trials
86 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | A41.9 | — | 7 | 3 | 2 | 4 | 15 | |
| Thiamine deficiency | D013832 | E51 | 3 | 3 | — | 4 | 2 | 12 | |
| Septic shock | D012772 | A48.3 | 2 | 7 | 3 | 1 | 1 | 12 | |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | 1 | 1 | 2 | 1 | 6 |
| Lactic acidosis | D000140 | EFO_1000036 | E87.20 | 1 | 2 | 1 | 2 | — | 5 |
| Fatigue | D005221 | HP_0012378 | R53.83 | — | — | — | 3 | — | 3 |
| Critical illness | D016638 | — | 2 | — | 1 | — | 3 | ||
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | 1 | 2 | 3 |
| Covid-19 | D000086382 | U07.1 | — | — | 1 | 1 | — | 2 | |
| Vitamin b 12 deficiency | D014806 | EFO_0000734 | E53.8 | — | — | — | 1 | — | 1 |
Show 14 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wounds and injuries | D014947 | T14.8 | — | — | 1 | — | 1 | 2 | |
| Hyperemesis gravidarum | D006939 | EFO_1000971 | O21 | — | — | 1 | — | — | 1 |
| Mycobacterium tuberculosis | D009169 | — | — | 1 | — | — | 1 | ||
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | 1 | — | — | 1 |
| Acute lung injury | D055371 | EFO_0004610 | — | 1 | 1 | — | — | 1 | |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 1 | — | — | 1 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart arrest | D006323 | EFO_0009492 | I46 | — | 3 | — | — | — | 3 |
| Delirium | D003693 | R41.0 | — | 1 | — | — | 1 | 2 | |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | 1 | — | — | 1 | 2 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | 1 | — | — | — | 1 |
| Migraine with aura | D020325 | EFO_0005295 | G43.1 | 1 | 1 | — | — | — | 1 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 1 | 1 | — | — | — | 1 |
| Huntington disease | D006816 | G10 | — | 1 | — | — | — | 1 | |
| Alcohol-induced disorders | D020751 | — | 1 | — | — | — | 1 | ||
| Diabetic ketoacidosis | D016883 | EFO_1000897 | — | 1 | — | — | — | 1 | |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | 1 | — | — | — | 1 |
Show 8 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Beriberi | D001602 | EFO_1000837 | E51.1 | 1 | — | — | — | 1 | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | — | — | — | 1 | 1 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | — | — | — | 1 | 1 |
| Carbohydrate-restricted diet | D050528 | — | — | — | — | 1 | 1 | ||
| Hyperlactatemia | D065906 | — | — | — | — | 1 | 1 | ||
| Thyrotoxicosis | D013971 | E05 | — | — | — | — | 1 | 1 | |
| Sciatica | D012585 | HP_0011868 | M54.3 | — | — | — | — | 1 | 1 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | — | 1 | 1 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | — | — | 1 | 1 |
| Diabetes complications | D048909 | — | — | — | — | 1 | 1 |
Show 3 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | THIAMINE |
| INN | thiamine |
| Description | Thiamine(1+) is a primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a primary alcohol and a vitamin B1. It is a conjugate base of a thiamine(2+). |
| Classification | Small molecule |
| Drug class | vitamin |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ncc(C[n+]2csc(CCO)c2C)c(N)n1.[Cl-] |
Identifiers
| PDB | — |
| CAS-ID | 59-43-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1588 |
| ChEBI ID | 33283 |
| PubChem CID | 1130 |
| DrugBank | DBSALT002650 |
| UNII ID | X66NSO3N35 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SLC19A2
SLC19A2
SLC19A3
SLC19A3
Organism
Homo sapiens
Gene name
SLC19A2
Gene synonyms
THT1, TRMA
NCBI Gene ID
Protein name
thiamine transporter 1
Protein synonyms
high affinity thiamine transporter, reduced folate carrier protein (RFC) like, solute carrier family 19 (thiamine transporter), member 2, Solute carrier family 19 member 2, TC1, Thiamine carrier 1, thiamine-responsive megaloblastic anaemia, thTr-1
Uniprot ID
Mouse ortholog
Slc19a2 (116914)
thiamine transporter 1 (Q9EQN9)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,067 adverse events reported
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