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Theophylline
Accurbron, Aerolate, Aquaphyllin, Bronkodyl, Duraphyl, Elixicon, Elixomin, Elixophyllin, Labid, Lanophyllin, Quibron-t, Quibron-t/sr, Slo-bid, Slo-phyllin, Somophyllin-crt, Somophyllin-t, Sustaire, T-phyl, Theo-dur, Theobid, Theochron, Theoclear, Theolair, Theolair-sr, Theolixir, Theophyl, Theophyl-sr, Theovent, Uni-dur (theophylline) is a small molecule pharmaceutical. Theophylline was first approved as Mersalyl-theophylline on 1982-01-01. It is used to treat apnea, asthma, bradycardia, bronchial spasm, and bronchitis amongst others in the USA. The pharmaceutical is active against adenosine receptor A2a and adenosine receptor A2b. In addition, it is known to target adenosine receptor A3 and adenosine receptor A1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
cardiovascular diseasesD002318
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Procaine merethoxylline
+
Theophylline
Tradename
Company
Number
Date
Products
DICURIN PROCAINEEli LillyN-008869 DISCN1982-01-01
1 products
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Theophylline
Tradename
Company
Number
Date
Products
THEOPHYLLINE 0.04% AND DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019826 RX1992-08-14
1 products, RLD, RS
THEOPHYLLINE 0.08% AND DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019826 RX1992-08-14
1 products, RLD, RS
THEOPHYLLINE 0.16% AND DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019826 RX1992-08-14
1 products, RLD, RS
THEOPHYLLINE 0.32% AND DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019826 RX1992-08-14
1 products, RLD, RS
Show 9 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
elixophyllinANDA2018-02-06
theophyllineANDA2023-06-09
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
apneaHP_0002104D001049R06.81
asthmaEFO_0000270D001249J45
bradycardiaHP_0001662D001919R00.1
bronchial spasm—D001986—
bronchitis—D001991J40
pulmonary emphysema—D011656J43
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03D: Other systemic drugs for obstructive airway diseases in atc
— R03DA: Xanthines, systemic for obstructive airway disease
— R03DA04: Theophylline
— R03DA54: Theophylline, combinations excl. psycholeptics
— R03DA74: Theophylline, combinations with psycholeptics
— R03DB: Xanthines and adrenergics
— R03DB04: Theophylline and adrenergics
HCPCS
Code
Description
J2810
Injection, theophylline, per 40 mg
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTHEOPHYLLINE
INN—
Description
Theophylline is a dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea. It has a role as a vasodilator agent, a bronchodilator agent, a muscle relaxant, an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor, an anti-asthmatic drug, an anti-inflammatory agent, an immunomodulator, an adenosine receptor antagonist, a drug metabolite, a fungal metabolite and a human blood serum metabolite.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cn1c(=O)c2[nH]cnc2n(C)c1=O
Identifiers
PDB5MZJ
CAS-ID58-55-9
RxCUI91178
ChEMBL IDCHEMBL190
ChEBI ID28177
PubChem CID2153
DrugBankDB00277
UNII ID—
Target
Agency Approved
ADORA2A
ADORA2A
ADORA2B
ADORA2B
Organism
Homo sapiens
Gene name
ADORA2A
Gene synonyms
ADORA2
NCBI Gene ID
135
Protein name
adenosine receptor A2a
Protein synonyms
adenosine receptor subtype A2a
Uniprot ID
P29274
Mouse ortholog
Adora2a (11540)
adenosine receptor A2a (Q60613)
Alternate
ADORA3
ADORA3
ADORA1
ADORA1
Organism
Homo sapiens
Gene name
ADORA3
Gene synonyms
NCBI Gene ID
140
Protein name
adenosine receptor A3
Protein synonyms
Uniprot ID
Q9BYZ1
Mouse ortholog
—
—
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 395 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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131 adverse events reported
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