Tezacitabine
Tezacitabine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Therapeutic Areas
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Indications
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Agency Specific
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
49 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pneumonia | D011014 | EFO_0003106 | J18 | — | 1 | 2 | 2 | 3 | 7 |
| Appendicitis | D001064 | EFO_0007149 | K37 | — | — | — | 2 | 2 | 4 |
| Intraabdominal infections | D059413 | — | 1 | 1 | 2 | — | 3 | ||
| Nephrolithiasis | D053040 | N20.0 | — | — | — | 1 | 1 | 2 | |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | — | 1 | 1 | 2 |
| Necrotizing enterocolitis | D020345 | EFO_0003928 | K55.3 | — | — | — | 1 | 1 | 2 |
| Cholelithiasis | D002769 | EFO_0004799 | K80 | — | — | — | 2 | — | 2 |
| Neonatal sepsis | D000071074 | HP_0040187 | — | 1 | 1 | 1 | — | 2 | |
| Wound infection | D014946 | — | — | — | 1 | — | 1 | ||
| Open fractures | D005597 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | 1 | — | 1 | — | 1 | 3 | |
| Sepsis | D018805 | A41.9 | — | 1 | 1 | — | 1 | 3 | |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | 2 | — | 1 | 3 |
| Chorioamnionitis | D002821 | O41.12 | — | 2 | 2 | — | 1 | 3 | |
| Lung abscess | D008169 | EFO_1001362 | J85.2 | — | — | 1 | — | 1 | 2 |
| Kidney calculi | D007669 | EFO_0004253 | N20.0 | — | — | 1 | — | — | 1 |
| Aspiration pneumonia | D011015 | EFO_1001399 | J69.0 | — | — | 1 | — | — | 1 |
| Meningitis | D008581 | EFO_0000584 | G03 | — | 1 | 1 | — | — | 1 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | — | 1 | — | — | 1 |
| Child nutrition disorders | D015362 | — | 1 | 1 | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Jaw fractures | D007572 | 1 | — | — | — | — | 1 | ||
| Dystonia | D004421 | HP_0001332 | G24 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Salmonella infections | D012480 | EFO_1001418 | A02.9 | — | — | — | — | 1 | 1 |
| Endometritis | D004716 | EFO_1001312 | — | — | — | — | 1 | 1 | |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | — | 1 | 1 |
| Peritonitis | D010538 | EFO_0008588 | K65 | — | — | — | — | 1 | 1 |
| Listeria monocytogenes | D008089 | NCBITaxon_1639 | — | — | — | — | 1 | 1 | |
| Gastrointestinal diseases | D005767 | — | — | — | — | 1 | 1 | ||
| Colic | D003085 | HP_0011848 | R10.83 | — | — | — | — | 1 | 1 |
| Premature obstetric labor | D007752 | O60 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TEZACITABINE |
| INN | tezacitabine |
| Description | Tezacitabine is a ribonucleotide reductase inhibitor. It is a synthetic purine nucleoside analogue with potential antineoplastic activity. It is used in synthetic DNA.
|
| Classification | Small molecule |
| Drug class | nucleoside antiviral or antineoplastic agents, cytarabine or azarabine derivatives |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)/C2=C\F)c(=O)n1 |
Identifiers
| PDB | — |
| CAS-ID | 130306-02-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2105467 |
| ChEBI ID | — |
| PubChem CID | 6435808 |
| DrugBank | — |
| UNII ID | 7607Y95N9S (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 13 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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5,180 adverse events reported
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