Tetrahydrozoline
Tetrahydrozoline is a small molecule pharmaceutical. Tetrahydrozoline was first approved as Tyzine on 1982-01-01. It is used to treat hyperemia, sinusitis, and vasomotor rhinitis in the USA.
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EMA
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| good neighbor pharmacy eye drops multi-symptom relief | OTC monograph final | 2023-06-05 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hyperemia | EFO_0003822 | D006940 | H34.82 |
| sinusitis | EFO_0007486 | D012852 | J32 |
| vasomotor rhinitis | EFO_0007533 | D012223 | J30.0 |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AA: Sympathomimetics, plain
— R01AA06: Tetryzoline
— R01AB: Sympathomimetics, combinations excl. corticosteroids
— R01AB03: Tetryzoline
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01G: Decongestants and antiallergics
— S01GA: Sympathomimetics used as decongestants
— S01GA02: Tetryzoline
— S01GA52: Tetryzoline, combinations
HCPCS
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Clinical
Clinical Trials
92 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | 2 | 4 | 9 | 8 | 3 | 26 |
| Anesthesia | D000758 | 1 | 3 | 4 | 1 | 1 | 10 | ||
| Healthy volunteers/patients | — | 3 | — | — | 2 | — | 5 | ||
| Local anesthesia | D000772 | — | 1 | 1 | 1 | 1 | 3 | ||
| Lacerations | D022125 | — | 1 | — | 2 | — | 3 | ||
| Linear energy transfer | D018499 | — | — | — | 2 | — | 2 | ||
| Procedural pain | D000073818 | — | — | 1 | 1 | — | 2 | ||
| Labor pain | D048949 | — | — | — | 1 | — | 1 | ||
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | 1 | — | 1 |
| Pulpitis | D011671 | EFO_1001139 | K04.0 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Corneal injuries | D065306 | HP_0000559 | — | 1 | 2 | — | 1 | 3 | |
| Cataract | D002386 | EFO_0001059 | H26.9 | — | — | 2 | — | 1 | 3 |
| Behavior | D001519 | GO_0007610 | STY/T053 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dental caries | D003731 | EFO_0003819 | K02 | — | 3 | — | — | — | 3 |
| Periapical periodontitis | D010485 | EFO_1001391 | K04.5 | — | 3 | — | — | — | 3 |
| Phlebotomy | D018962 | — | 2 | — | — | — | 2 | ||
| Shoulder pain | D020069 | HP_0030834 | M25.51 | — | 1 | — | — | — | 1 |
| Palliative care | D010166 | — | 1 | — | — | — | 1 | ||
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | 1 | 1 | — | — | — | 1 |
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | 1 | — | — | — | 1 | |
| Shoulder impingement syndrome | D019534 | EFO_1001178 | M75.4 | — | 1 | — | — | — | 1 |
| Carpal tunnel syndrome | D002349 | EFO_0004143 | G56.0 | — | 1 | — | — | — | 1 |
| Postherpetic neuralgia | D051474 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Meniere disease | D008575 | EFO_0006862 | H81.0 | 1 | — | — | — | — | 1 |
| Sensorineural hearing loss | D006319 | HP_0000407 | H90.5 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | — | — | 3 | 3 |
| Macular edema | D008269 | — | — | — | — | 1 | 1 | ||
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | — | — | — | — | 1 | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | — | 1 | 1 |
| Personal satisfaction | D010549 | — | — | — | — | 1 | 1 | ||
| Analgesia | D000698 | — | — | — | — | 1 | 1 | ||
| Hysteroscopy | D015907 | — | — | — | — | 1 | 1 | ||
| Drug-related side effects and adverse reactions | D064420 | T88.7 | — | — | — | — | 1 | 1 | |
| Lentigo | D007911 | L81.4 | — | — | — | — | 1 | 1 | |
| Pharyngitis | D010612 | R07.0 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TETRAHYDROZOLINE |
| INN | tetryzoline |
| Description | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | c1ccc2c(c1)CCCC2C1=NCCN1 |
Identifiers
| PDB | — |
| CAS-ID | 84-22-0 |
| RxCUI | 37935 |
| ChEMBL ID | CHEMBL1266 |
| ChEBI ID | 28674 |
| PubChem CID | 5419 |
| DrugBank | DB06764 |
| UNII ID | S9U025Y077 (ChemIDplus, GSRS) |
Target
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Alternate
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Variants
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Trends
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Safety
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Adverse Events
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530 adverse events reported
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