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Tetracycline
Achromycin, Helidac, Pylera, Tetracyn, Tetrex (tetracycline) is a small molecule pharmaceutical. Tetracycline was first approved as Achromycin on 1982-01-01. It is used to treat acne vulgaris, bacterial eye infections, bacterial infections, bartonella infections, and borrelia infections amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
eye diseasesD005128
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Achromycin (generic drugs available since 1982-01-01, discontinued: Actisite, Bristacycline, Cyclopar, Panmycin, Retet, Robitet, Sumycin, Tetrachel, Tetracyn, Tetramed, Tetrex, Topicycline)
Combinations
Pylera (generic drugs available since 1982-01-01, discontinued: Achromycin, Helidac, Tetracyn)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bismuth subcitrate potassium
+
Metronidazole
+
Tetracycline hydrochloride
Tradename
Company
Number
Date
Products
PYLERAAbbVieN-050786 RX2006-09-28
1 products, RLD, RS
Bismuth subsalicylate
+
Metronidazole
+
Tetracycline hydrochloride
Tradename
Company
Number
Date
Products
HELIDACCasper PharmaN-050719 DISCN1996-08-15
1 products, RLD
Hide discontinued
Hydrocortisone
+
Tetracycline hydrochloride
Tradename
Company
Number
Date
Products
ACHROMYCINLederle LaboratoriesN-050272 DISCN1982-01-01
1 products
Hide discontinued
Procaine hydrochloride
+
Tetracycline hydrochloride
Tradename
Company
Number
Date
Products
ACHROMYCINLederle LaboratoriesN-050276 DISCN1982-01-01
2 products
Hide discontinued
Tetracycline hydrochloride
Tradename
Company
Number
Date
Products
ACHROMYCIN VAvet LifesciencesN-050278 RX1982-01-01
2 products, RLD
Show 6 discontinued
Tetracycline phosphate complex
Tradename
Company
Number
Date
Products
TETREXBristol Myers SquibbN-050212 DISCN1982-01-01
2 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
helidac therapyANDA2020-06-17
pyleraNew Drug Application2021-12-15
tetracycline hydrochlorideANDA2023-05-25
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acne vulgarisEFO_0003894D000152L70
bacterial eye infectionsD015818
bacterial infectionsD001424A49
bartonella infectionsEFO_0007166D001474A44
borrelia infectionsEFO_1000842D001899
bronchitisD001991J40
campylobacter infectionsEFO_0007190D002169
chancroidD002602A57
chlamydia infectionsEFO_0007205D002690A74.9
choleraD002771A00
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A01: Stomatological preparations
A01A: Stomatological preparations
A01AB: Antiinfectives and antiseptics for local oral treatment
A01AB13: Tetracycline
A02: Drugs for acid related disorders
A02B: Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
A02BD: Combinations for eradication of helicobacter pylori
A02BD02: Lansoprazole, tetracycline and metronidazole
A02BD08: Bismuth subcitrate, tetracycline and metronidazole
D: Dermatologicals
D06: Antibiotics and chemotherapeutics for dermatological use
D06A: Antibiotics for topical use
D06AA: Tetracycline and derivatives, topical antibiotics
D06AA04: Tetracycline
J: Antiinfectives for systemic use
J01: Antibacterials for systemic use
J01A: Tetracycline antibiotics
J01AA: Tetracyclines
J01AA07: Tetracycline
J01R: Combinations of antibacterials
J01RA: Combinations of antibacterials
J01RA08: Tetracycline and oleandomycin
S: Sensory organ drugs
S01: Ophthalmologicals
S01A: Antiinfective ophthalmologics
S01AA: Antibiotics, ophthalmologic
S01AA09: Tetracycline
S02: Otologicals
S02A: Antiinfective drugs, otologic
S02AA: Antiinfectives
S02AA08: Tetracycline
S03: Ophthalmological and otological preparations
S03A: Antiinfectives, ophthalmologic and otologic
S03AA: Antiinfectives
S03AA02: Tetracycline
HCPCS
Code
Description
J0120
Injection, tetracycline, up to 250 mg
J2460
Injection, oxytetracycline hcl, up to 50 mg
Clinical
Clinical Trials
84 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_00005441125532
GastritisD005756EFO_0000217K29.71214
Helicobacter infectionsD016481EFO_10009611214
Stomach neoplasmsD013274EFO_0003897C16123
OsteoporosisD010024EFO_0003882M81.022
Helicobacter pyloriD016480NCBITaxon_210B96.81112
TrichiasisD058457HP_000112811
Peptic ulcerD010437HP_0004398K2711
DyspepsiaD004415EFO_0008533K3011
DysbiosisD06480611
Show 3 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bacterial vaginosisD016585EFO_000393222
TrachomaD014141A7111
Vulvovaginal candidiasisD002181EFO_0007543B37.311
CandidiasisD002177B3711
BurnsD002056T30.0111
PeriodontitisD010518EFO_0000649K05.311
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223C85.922
Lung neoplasmsD008175C34.9011
ExanthemaD005076R2111
Non-hodgkin lymphomaD008228C85.911
Chronic periodontitisD055113EFO_0006343K05.311
Hiv infectionsD015658EFO_0000764B2011
Post-lyme disease syndromeD00007734211
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Malignant pleural effusionD016066J91.011
Healthy volunteers/patients11
ChalazionD017043EFO_0007363H00.111
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Gingival recessionD005889K06.022
NeoplasmsD009369C8011
Head and neck neoplasmsD00625811
Dry eye syndromesD015352H04.1211
ParonychiaD010304EFO_0007421L03.011
Breast neoplasmsD001943EFO_0003869C5011
Covid-19D000086382U07.111
PneumothoraxD011030J93.1111
Wound infectionD01494611
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTETRACYCLINE
INNtetracycline
Description
Tetracycline is a broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria. It has a role as an antimicrobial agent, an antibacterial drug, an antiprotozoal drug, a protein synthesis inhibitor and an Escherichia coli metabolite. It is a tertiary alpha-hydroxy ketone and a member of tetracyclines. It is a conjugate acid of a tetracycline(1-) and a tetracycline zwitterion.
Classification
Small molecule
Drug classantibiotics (tetracycline derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)cccc4[C@@](C)(O)[C@H]3C[C@@H]12
Identifiers
PDB
CAS-ID60-54-8
RxCUI10395
ChEMBL IDCHEMBL1440
ChEBI ID27902
PubChem CID54675776
DrugBankDB00759
UNII IDF8VB5M810T (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 128,754 documents
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Safety
Black-box Warning
Black-box warning for: Helidac therapy, Pylera
Adverse Events
Top Adverse Reactions
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35,815 adverse events reported
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