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Terbutaline
Brethine (terbutaline) is a small molecule pharmaceutical. Terbutaline was first approved as Brethine on 1982-01-01. It is used to treat asthma in the USA. The pharmaceutical is active against beta-2 adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
immune system diseasesD007154
Trade Name
FDA
EMA
Brethine (generic drugs available since 2001-06-26, discontinued: Brethaire, Bricanyl)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Terbutaline sulfate
Tradename
Company
Number
Date
Products
BRETHINEANI PHARMSN-017849 RX1982-01-01
2 products, RLD
Show 5 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
terbutaline sulfateANDA2023-05-23
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
asthmaEFO_0000270D001249J45
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
R03: Drugs for obstructive airway diseases
R03A: Adrenergics, inhalants
R03AC: Selective beta-2-adrenoreceptor agonist inhalants
R03AC03: Terbutaline
R03C: Adrenergics for systemic use
R03CC: Selective beta-2-adrenoreceptor agonists, systemic
R03CC03: Terbutaline
R03CC53: Terbutaline, combinations
HCPCS
Code
Description
J3105
Injection, terbutaline sulfate, up to 1 mg
J7680
Terbutaline sulfate, inhalation solution, compounded product, administered through dme, concentrated form, per milligram
J7681
Terbutaline sulfate, inhalation solution, compounded product, administered through dme, unit dose form, per milligram
Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I10112
Prostatic hyperplasiaD011470EFO_0000284N40112
Type 2 diabetes mellitusD003924EFO_0001360E1111
HyperhidrosisD006945HP_000097511
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Secondary parkinson diseaseD010302EFO_1001175G2122
Rem sleep behavior disorderD020187EFO_0007462G47.5222
DementiaD003704F03111
Parkinson diseaseD010300EFO_0002508G20111
Carotid stenosisD01689311
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients11
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Lower urinary tract symptomsD059411EFO_000800811
NocturiaD053158R35.111
Urinary retentionD016055HP_0000016R3311
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTERBUTALINE
INNterbutaline
Description
Terbutaline is a member of the class of phenylethanolamines that is catechol substuted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group. It has a role as a beta-adrenergic agonist, an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an anti-asthmatic drug, a bronchodilator agent, a sympathomimetic agent, a tocolytic agent and a hypoglycemic agent. It is a member of phenylethanolamines and a member of resorcinols.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)(C)NCC(O)c1cc(O)cc(O)c1
Identifiers
PDB
CAS-ID23031-25-6
RxCUI10368
ChEMBL IDCHEMBL1760
ChEBI ID9449
PubChem CID5403
DrugBankDB00871
UNII IDN8ONU3L3PG (ChemIDplus, GSRS)
Target
Agency Approved
ADRB2
ADRB2
Organism
Homo sapiens
Gene name
ADRB2
Gene synonyms
ADRB2R, B2AR
NCBI Gene ID
Protein name
beta-2 adrenergic receptor
Protein synonyms
adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor
Uniprot ID
Mouse ortholog
Adrb2 (11555)
beta-2 adrenergic receptor (Q8BH38)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 5,294 documents
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Safety
Black-box Warning
Black-box warning for: Terbutaline sulfate
Adverse Events
Top Adverse Reactions
Mock data
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1,758 adverse events reported
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