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Viread(tenofovir disoproxil)
Atripla, Cimduo, Complera, Delstrigo, Eviplera, Stribild, Symfi, Truvada, Viread (tenofovir disoproxil) is a small molecule pharmaceutical. Tenofovir disoproxil was first approved as Viread on 2001-10-26. It is used to treat chronic hepatitis b and HIV in the USA. It has been approved in Europe to treat chronic hepatitis b and HIV infections.
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BMS
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
urogenital diseasesD000091642
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Viread (generic drugs available since 2015-03-18)
Combinations
Atripla, Cimduo, Complera, Delstrigo, Stribild, Symfi, Symfi lo, Truvada (generic drugs available since 2015-03-18, discontinued: Temixys)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cobicistat
+
Elvitegravir
+
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
STRIBILDGilead SciencesN-203100 RX2012-08-27
1 products, RLD, RS
Doravirine
+
Lamivudine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
DELSTRIGOMerck Sharp & DohmeN-210807 RX2018-08-30
1 products, RLD, RS
Efavirenz
+
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
ATRIPLAGilead SciencesN-021937 RX2006-07-12
1 products, RLD, RS
Efavirenz
+
Lamivudine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
SYMFI LOMylanN-208255 RX2018-02-05
1 products, RLD, RS
SYMFIMylanN-022142 RX2018-03-22
1 products, RLD, RS
Show 2 discontinued
Emtricitabine
+
Rilpivirine hydrochloride
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
COMPLERAGilead SciencesN-202123 RX2011-08-10
1 products, RLD, RS
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
TRUVADAGilead SciencesN-021752 RX2004-08-02
4 products, RLD, RS
Lamivudine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
CIMDUOMylanN-022141 RX2018-02-28
1 products, RLD, RS
Show 2 discontinued
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
VIREADGilead SciencesN-021356 RX2001-10-26
4 products, RLD, RS
VIREADGilead SciencesN-022577 RX2012-01-18
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
atriplaNew Drug Application2021-12-14
cimduoNew Drug Application2021-02-15
complera accessExport only2021-03-29
delstrigoNew Drug Application2021-10-31
efavirenz, emtricitabine and tenofovir disoproxil fumarateANDA2023-01-27
emtricitabine and tenofovir disoproxil fumarateANDA2023-06-15
stribildNew Drug Application2021-09-16
symfiNew Drug Application2019-10-15
temixysNew Drug Application2021-01-25
truvadaNew Drug Application2022-01-20
Show 1 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
chronic hepatitis bEFO_0004239D019694B18.1
hivD006678O98.7
Agency Specific
FDA
EMA
Expiration
Code
DORAVIRINE / LAMIVUDINE / TENOFOVIR DISOPROXIL FUMARATE, DELSTRIGO, MSD MERCK CO
2025-01-27NPP
2023-08-30NCE
Patent Expiration
Patent
Expires
Flag
FDA Information
Doravirine / Lamivudine / Tenofovir Disoproxil Fumarate, Delstrigo, Msd Merck Co
106032822036-11-29DP
108427512036-11-29DP
84869752031-10-07DS, DPU-2395, U-2629, U-3307
Emtricitabine / Rilpivirine Hydrochloride / Tenofovir Disoproxil Fumarate, Complera, Gilead Sciences Inc
108571022033-01-14DP
88413102025-12-09DPU-257
71258792025-04-21DS, DPU-257
80805512023-04-11DS, DP
Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Disoproxil Fumarate, Stribild, Gilead Sciences Inc
100397182032-10-06DP
86332192030-04-30DPU-257
81483742029-09-03DS, DPU-1279
98912392029-09-03DPU-257
76357042026-10-26DS, DPU-257
89811032026-10-26DS, DP
71762202026-08-27DS, DPU-257
85923972024-01-13DPU-248, U-257, U-541, U-750, U-1170
87162642024-01-13DPU-257
94570362024-01-13DPU-257
97441812024-01-13DPU-257
Efavirenz / Emtricitabine / Tenofovir Disoproxil Fumarate, Atripla, Gilead Sciences
85981852029-04-28DP
90181922026-06-13U-750, U-1170
95454142026-06-13DPU-750, U-1170
ATC Codes
J: Antiinfectives for systemic use
J05: Antivirals for systemic use
J05A: Direct acting antivirals
J05AF: Nucleoside and nucleotide reverse transcriptase inhibitors
J05AF07: Tenofovir disoproxil
J05AR: Antivirals for treatment of hiv infections, combinations
J05AR03: Tenofovir disoproxil and emtricitabine
J05AR06: Emtricitabine, tenofovir disoproxil and efavirenz
J05AR08: Emtricitabine, tenofovir disoproxil and rilpivirine
J05AR09: Emtricitabine, tenofovir disoproxil, elvitegravir and cobicistat
J05AR11: Lamivudine, tenofovir disoproxil and efavirenz
J05AR12: Lamivudine and tenofovir disoproxil
J05AR24: Lamivudine, tenofovir disoproxil and doravirine
J05AR27: Lamivudine, tenofovir disoproxil and dolutegravir
HCPCS
No data
Clinical
Clinical Trials
736 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B202971767748288
Chronic hepatitis bD019694EFO_0004197B18.11325173828117
HivD006678O98.71911144622110
Hepatitis bD0065095158161355
Healthy volunteers/patients216229
Acquired immunodeficiency syndromeD000163EFO_0000765B202262214
InfectionsD007239EFO_000054436312
Medication adherenceD055118EFO_00063443123110
Hiv-1D0154972349
PregnancyD011247EFO_0002950Z33.113228
Show 37 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382U07.13516
Sars-cov-2D000086402122
Chronic hepatitis dD019701112
LymphomaD008223C85.91112
Treatment adherence and complianceD00007482222
Breast feedingD00194211
Coronavirus infectionsD018352EFO_0007224B34.211
B-cell lymphomaD01639311
Disease progressionD01845011
Hiv seronegativityD018023111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatitis dD003699EFO_000730444
Biliary liver cirrhosisD008105K74.3112
Metabolic syndromeD024821EFO_0000195E88.81112
LipodystrophyD008060E88.122
ParasitemiaD018512111
Progressive multifocal leukoencephalopathyD007968EFO_0007455A81.211
Hiv seropositivityD00667911
Amphetamine-related disordersD019969EFO_0004701F1511
B-cell chronic lymphocytic leukemiaD015451C91.111
Large b-cell lymphoma diffuseD016403C83.311
Show 5 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug interactionsD004347112
ContraceptionD003267112
Gender dysphoriaD000068116F6411
TransgenesD01907611
Insulin resistanceD007333EFO_000261411
Amyotrophic lateral sclerosisD000690EFO_0000253G12.2111
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pregnancy rateD01887322
Risk reduction behaviorD04024222
Sustained virologic responseD00007223011
Job syndromeD007589EFO_0003775D82.411
InflammationD00724911
InfertilityD007246EFO_000054511
Liver failureD017093HP_0001399K72.911
Virus diseasesD014777B3411
ProteinuriaD011507HP_0000093R8011
HyperglycemiaD006943HP_0003074R73.911
Show 10 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTENOFOVIR DISOPROXIL
INNtenofovir
Description
Tenofovir (anhydrous) is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection. It has a role as a HIV-1 reverse transcriptase inhibitor, an antiviral drug and a drug metabolite. It is a member of phosphonic acids and a nucleoside analogue. It is a conjugate acid of a tenofovir(1-).
Classification
Small molecule
Drug classantivirals
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc21)OCOC(=O)OC(C)C
Identifiers
PDB
CAS-ID147127-20-6
RxCUI117466
ChEMBL IDCHEMBL1538
ChEBI ID63717
PubChem CID464205
DrugBankDB00300
UNII IDW4HFE001U5 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Complera - Gilead Sciences
$
£
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Truvada - Gilead Sciences
$
£
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Atripla - Gilead Sciences
$
£
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Viread - Gilead Sciences
$
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Stribild - Gilead Sciences
$
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 27,160 documents
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Safety
Black-box Warning
Black-box warning for: Atripla, Cimduo, Complera access, Delstrigo, Efavirenz, emtricitabine and tenofovir disoproxil fumarate, Emtricitabine and tenofovir disoproxil fumarate, Stribild, Symfi, Temixys, Truvada, Viread
Adverse Events
Top Adverse Reactions
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11,241 adverse events reported
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