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Tapinarof
Vtama (tapinarof) is a small molecule pharmaceutical. Tapinarof was first approved as Vtama on 2022-05-23. It is used to treat psoriasis in the USA. The pharmaceutical is active against aryl hydrocarbon receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Vtama
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tapinarof
Tradename
Company
Number
Date
Products
VTAMADermavant SciencesN-215272 RX2022-05-23
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
vtamaNew Drug Application2022-05-23
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
psoriasisEFO_0000676D011565L40
Agency Specific
FDA
EMA
Expiration
Code
TAPINAROF, VTAMA, DERMAVANT SCI
2027-05-23NCE
Patent Expiration
Patent
Expires
Flag
FDA Information
Tapinarof, Vtama, Dermavant Sci
115900882039-11-13U-2625
106476492038-11-13DP
115976922038-11-13DS, DP
101951602036-05-19DP
104267432036-05-19U-2625
114581082036-05-19DP
116125732036-05-19U-2625
116177242036-05-19DP
116229452036-05-19DP
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PsoriasisD011565EFO_0000676L402352113
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atopic dermatitisD003876EFO_0000274L20444——11
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTAPINAROF
INNtapinarof
Description
Tapinarof, also known as benvitimod and sold under the brand name Vtama, is a medication used for the treatment of plaque psoriasis. The medication is applied to the skin. Besides its use in medicine, tapinarof is a naturally occurring compound found in bacterial symbionts of nematodes which has antibiotic properties.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)c1c(O)cc(/C=C/c2ccccc2)cc1O
Identifiers
PDB—
CAS-ID79338-84-4
RxCUI—
ChEMBL IDCHEMBL259571
ChEBI ID—
PubChem CID133191
DrugBankDB06083
UNII ID84HW7D0V04 (ChemIDplus, GSRS)
Target
Agency Approved
AHR
AHR
Organism
Homo sapiens
Gene name
AHR
Gene synonyms
BHLHE76
NCBI Gene ID
196
Protein name
aryl hydrocarbon receptor
Protein synonyms
ah receptor, AH-receptor, aromatic hydrocarbon receptor, bHLHe76, Class E basic helix-loop-helix protein 76
Uniprot ID
Q13804
Mouse ortholog
Ahr (11622)
aryl hydrocarbon receptor (P30561)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 184 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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