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Astagraf Xl, Envarsus, Prograf, Protopic, Advagraf, Modigraf (tacrolimus) is a small molecule pharmaceutical. Tacrolimus was first approved as Astagraf Xl on 1994-04-08. It is used to treat atopic dermatitis and graft vs host disease in the USA. It has been approved in Europe to treat atopic dermatitis, graft rejection, kidney transplantation, and liver transplantation. The pharmaceutical is active against peptidyl-prolyl cis-trans isomerase FKBP1A. Prograf's patents are valid until 2028-08-30 (FDA).
Trade Name Advagraf, Envarsus, Modigraf, Protopic
Common Name Tacrolimus
Indication atopic dermatitis, graft rejection, graft vs host disease, kidney transplantation, liver transplantation
Drug Class Immunosuppressives: immunosuppressant, rapamycin derivatives
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