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Suprofen
Profenal (suprofen) is a small molecule pharmaceutical. Suprofen was first approved as Profenal on 1988-12-23. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Suprofen
Tradename
Company
Number
Date
Products
PROFENALAlcon ResearchN-019387 DISCN1988-12-23
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
profenal2006-02-23
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AE: Propionic acid derivatives, antiinflammatory and antirheumatic products
— M01AE07: Suprofen
HCPCS
No data
Clinical
Clinical Trials
112 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine disordersD008881EFO_0003821G43111027101874
HeadacheD006261HP_0002315R51——1135
Post-traumatic headacheD051298G44.3—1—1—2
Post-dural puncture headacheD051299———1—1
Tension-type headacheD018781HP_0012228G44.2———1—1
Primary headache disordersD051270G44.53———1—1
Cluster headacheD003027HP_0012199G44.00———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine without auraD020326EFO_0005296G43.0——2—24
Migraine with auraD020325EFO_0005295G43.1—11—13
EpilepsyD004827EFO_0000474G40.9—11——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R52—1———1
VomitingD014839HP_0002013R11.1—1———1
NauseaD009325HP_0002018R11.0—1———1
Secondary headache disordersD051271—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—12———315
Therapeutic equivalencyD0138102————2
OverweightD050177E66.31————1
PharmacokineticsD0105991————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ArthritisD001168EFO_0005856M05-M14————11
TendinopathyD052256EFO_1001434M77.9————11
SynovitisD013585EFO_0008997M67.5————11
SpasmD013035M62.83————11
RadiculopathyD011843M54.1————11
GoutD006073EFO_0004274M10————11
RosaceaD012393L71————11
Cognitive dysfunctionD060825G31.84————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSUPROFEN
INNsuprofen
Description
Suprofen is an aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antirheumatic drug, a peripheral nervous system drug and a drug allergen. It is a member of thiophenes, a monocarboxylic acid and an aromatic ketone.
Classification
Small molecule
Drug classanti-inflammatory/analgesic agents (ibuprofen type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C(=O)O)c1ccc(C(=O)c2cccs2)cc1
Identifiers
PDB6OCL
CAS-ID40828-46-4
RxCUI10255
ChEMBL IDCHEMBL956
ChEBI ID9362
PubChem CID5359
DrugBankDB00870
UNII ID988GU2F9PE (ChemIDplus, GSRS)
Target
Agency Approved
PTGS2
PTGS2
PTGS1
PTGS1
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
5743
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Q16876
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 257 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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22,452 adverse events reported
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