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Sulfamethizole
Microsul, Proklar, Thiosulfil (sulfamethizole) is a small molecule pharmaceutical. Sulfamethizole was first approved as Thiosulfil on 1982-01-01. It is used to treat gram-negative bacterial infections, gram-positive bacterial infections, and urinary tract infections in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
urogenital diseasesD000091642
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sulfamethizole
Tradename
Company
Number
Date
Products
THIOSULFILWyethN-008565 DISCN1982-01-01
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
gram-negative bacterial infections—D016905—
gram-positive bacterial infections—D016908—
urinary tract infectionsEFO_0003103D014552N39.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B05: Blood substitutes and perfusion solutions
— B05C: Irrigating solutions, blood substitutes and perfusion
— B05CA: Antiinfective irrigating solutions
— B05CA04: Sulfamethizole
D: Dermatologicals
— D06: Antibiotics and chemotherapeutics for dermatological use
— D06B: Chemotherapeutics for topical use
— D06BA: Sulfonamides, topical
— D06BA04: Sulfamethizole
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01E: Sulfonamides and trimethoprim antibacterials for systemic use
— J01EB: Short-acting sulfonamides
— J01EB02: Sulfamethizole
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AB: Sulfonamides, ophthalmologic antiinfectives
— S01AB01: Sulfamethizole
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSULFAMETHIZOLE
INNsulfamethizole
Description
Sulfamethizole is a sulfonamide consisting of a 1,3,4-thiadiazole nucleus with a methyl substituent at C-5 and a 4-aminobenzenesulfonamido group at C-2. It has a role as an antimicrobial agent, an EC 2.5.1.15 (dihydropteroate synthase) inhibitor, an antiinfective agent and a drug allergen. It is a sulfonamide, a member of thiadiazoles and a sulfonamide antibiotic.
Classification
Small molecule
Drug classantimicrobials (sulfonamides derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1
Identifiers
PDB—
CAS-ID144-82-1
RxCUI10179
ChEMBL IDCHEMBL1191
ChEBI ID9331
PubChem CID5328
DrugBankDB00576
UNII ID25W8454H16 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 456 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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