Streptokinase
Streptokinase is an enzyme pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| arterial occlusive diseases | EFO_0009085 | D001157 | — |
| myocardial infarction | EFO_0000612 | D009203 | I21 |
| pulmonary embolism | EFO_0003827 | D011655 | I26 |
| venous thrombosis | HP_0004936 | D020246 | I82.40 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B01: Antithrombotic agents
— B01A: Antithrombotic agents
— B01AD: Enzymes, antithrombotic
— B01AD01: Streptokinase
— B06: Other hematological agents in atc
— B06A: Other hematological agents in atc
— B06AA: Enzymes, hematological
— B06AA55: Streptokinase, combinations
HCPCS
Code | Description |
|---|---|
| J2995 | Injection, streptokinase, per 250,000 iu |
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | 1 | 1 | 2 | |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | — | — | — | 1 | 1 | 2 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | 1 | 1 | — | 2 | |
| Pleural effusion | D010996 | J90 | — | — | — | 1 | — | 1 | |
| Respiratory tract infections | D012141 | J06.9 | — | — | — | 1 | — | 1 | |
| Reperfusion injury | D015427 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 3 | — | — | 3 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | 2 | — | — | 2 |
| Coronary disease | D003327 | — | — | 2 | — | — | 2 | ||
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | 2 | — | — | 2 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 2 | — | — | 2 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | — | 1 | — | — | 1 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| St elevation myocardial infarction | D000072657 | — | — | — | — | 1 | 1 | ||
| Non-st elevated myocardial infarction | D000072658 | — | — | — | — | 1 | 1 | ||
| Unstable angina | D000789 | EFO_1000985 | I20.0 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | STREPTOKINASE |
| INN | streptokinase |
| Description | Streptokinase is a thrombolytic medication activating plasminogen by nonenzymatic mechanism. As a medication it is used to break down clots in some cases of myocardial infarction (heart attack), pulmonary embolism, and arterial thromboembolism. The type of heart attack it is used in is an ST elevation myocardial infarction (STEMI). It is given by injection into a vein.
|
| Classification | Enzyme |
| Drug class | enzymes |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | 1BML, 1C4P, 1L4D, 1L4Z, 1QQR |
| CAS-ID | 9002-01-1 |
| RxCUI | 10106 |
| ChEMBL ID | CHEMBL2108147 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00086 |
| UNII ID | 8X1OXL3SNU (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 10,324 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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11 adverse events reported
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