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Siremadlin
Siremadlin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470C92.043———4
NeoplasmsD009369C8011———2
Primary myelofibrosisD055728D47.411———1
SarcomaD01250911———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD0022891————1
Colorectal neoplasmsD0151791————1
Uveal neoplasmsD014604EFO_10012301————1
LiposarcomaD0080801————1
Hepatic insufficiencyD0485501————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSIREMADLIN
INNsiremadlin
Description
Siremadlin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
Classification
Small molecule
Drug classubiquitin ligase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ncc(-c2nc3c(n2C(C)C)[C@H](c2ccc(Cl)cc2)N(c2cc(Cl)cn(C)c2=O)C3=O)c(OC)n1
Identifiers
PDB—
CAS-ID1448867-41-1
RxCUI—
ChEMBL IDCHEMBL3653256
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID0282IF4JC8 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 61 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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11 adverse events reported
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