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Sylvant(siltuximab)
Sylvant (siltuximab) is an antibody pharmaceutical. Siltuximab was first approved as Sylvant on 2014-04-23. It is used to treat castleman disease in the USA. It has been approved in Europe to treat focal nodular hyperplasia. The pharmaceutical is active against interleukin-6.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
hemic and lymphatic diseasesD006425
immune system diseasesD007154
Trade Name
FDA
EMA
Sylvant
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Siltuximab
Tradename
Proper name
Company
Number
Date
Products
SylvantsiltuximabEUSA PharmaN-125496 RX2014-04-23
2 products
Labels
FDA
EMA
Brand Name
Status
Last Update
sylvantBiologic Licensing Application2020-02-26
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
castleman diseaseEFO_1001332D005871D47.Z2
Agency Specific
FDA
EMA
Expiration
Code
siltuximab, Sylvant, EUSA Pharma (UK) Limited
2121-04-23Orphan excl.
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
L04: Immunosuppressants
L04A: Immunosuppressants
L04AC: Interleukin inhibitors
L04AC11: Siltuximab
HCPCS
Code
Description
J2860
Injection, siltuximab, 10 mg
Clinical
Clinical Trials
33 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101C90.03519
Covid-19D000086382U07.1112
Respiratory distress syndromeD012128EFO_1000637J8011
Respiratory tract infectionsD012141J06.911
Respiratory tract diseasesD01214011
PneumoniaD011014EFO_0003106J1811
Lung diseasesD008171EFO_0003818J98.411
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61123
Non-hodgkin lymphomaD008228C85.9213
Pancreatic neoplasmsD010190EFO_0003860C25222
Colorectal neoplasmsD015179111
Ovarian neoplasmsD010051EFO_0003893C56111
Head and neck neoplasmsD006258111
Lung neoplasmsD008175C34.90111
Immunoglobulin light-chain amyloidosisD00007536311
SchizophreniaD012559EFO_0000692F20111
Psychotic disordersD011618F20.81111
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Polycythemia veraD011087D4511
Primary myelofibrosisD055728D47.411
ThrombocytopeniaD013921HP_0001873D69.611
Type 1 diabetes mellitusD003922EFO_0001359E1011
Healthy volunteers/patients11
Plasma cell neoplasmsD05421911
Monoclonal gammopathy of undetermined significanceD008998D47.211
Castleman diseaseD005871EFO_1001332D47.Z211
Large granular lymphocytic leukemiaD05406611
Myeloid leukemia acuteD015470C92.011
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSILTUXIMAB
INNsiltuximab
Description
Siltuximab (chimeric mab)
Classification
Antibody
Drug classmonoclonal antibodies
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB
CAS-ID541502-14-1
RxCUI1535218
ChEMBL IDCHEMBL1743070
ChEBI ID
PubChem CID
DrugBankDB09036
UNII IDT4H8FMA7IM (ChemIDplus, GSRS)
Target
Agency Approved
IL6
IL6
Organism
Homo sapiens
Gene name
IL6
Gene synonyms
IFNB2
NCBI Gene ID
Protein name
interleukin-6
Protein synonyms
B-cell differentiation factor, B-cell stimulatory factor 2, BSF-2, CDF, CTL differentiation factor, Hybridoma growth factor, IFN-beta-2, Interferon beta-2, interleukin BSF-2
Uniprot ID
Mouse ortholog
Il6 (16193)
interleukin-6 (P08505)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 2,589 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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2,121 adverse events reported
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