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Semagacestat
Semagacestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against presenilin-1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alzheimer diseaseD000544EFO_0000249F031135
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSEMAGACESTAT
INNsemagacestat
Description
(2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide is a peptide.
Classification
Small molecule
Drug classenzyme inhibitors: gamma secretase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)[C@H](O)C(=O)N[C@@H](C)C(=O)N[C@@H]1C(=O)N(C)CCc2ccccc21
Identifiers
PDB
CAS-ID425386-60-3
RxCUI
ChEMBL IDCHEMBL520733
ChEBI ID
PubChem CID9843750
DrugBankDB12463
UNII ID3YN0602W4W (ChemIDplus, GSRS)
Target
Agency Approved
PSEN1
PSEN1
Organism
Homo sapiens
Gene name
PSEN1
Gene synonyms
AD3, PS1, PSNL1
NCBI Gene ID
Protein name
presenilin-1
Protein synonyms
familial Alzheimer Disease, Protein S182
Uniprot ID
Mouse ortholog
Psen1 (19164)
presenilin-1 (Q9JLP9)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 805 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2 adverse events reported
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