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Saredutant
Saredutant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target substance-K receptor, substance-P receptor, and neuromedin-K receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Depressive disorderD003866EFO_1002014F32.A——8——8
Major depressive disorderD003865EFO_0003761F22——2——2
AnxietyD001007EFO_0005230F41.1——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSAREDUTANT
INNsaredutant
Description
Saredutant (SR-48,968) is a drug that acts as a NK2 receptor antagonist. It was under development by Sanofi-Aventis as a novel antidepressant and anxiolytic and made it to phase III clinical trials. However, in May 2009, Sanofi-Aventis published its quarterly results and announced the cessation of 14 research/development projects, among which was saredutant for the treatment of major depressive disorder.
Classification
Small molecule
Drug classtachykinin (neurokinin) receptor antagonists: NK2 receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)NC1(c2ccccc2)CCN(CC[C@H](CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1
Identifiers
PDB—
CAS-ID142001-63-6
RxCUI—
ChEMBL IDCHEMBL308148
ChEBI ID—
PubChem CID104974
DrugBankDB06660
UNII ID720U2QK8I5 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TACR2
TACR2
TACR1
TACR1
TACR3
TACR3
Organism
Homo sapiens
Gene name
TACR2
Gene synonyms
NK2R, NKNAR, TAC2R
NCBI Gene ID
6865
Protein name
substance-K receptor
Protein synonyms
neurokinin 2 receptor, Neurokinin A receptor, neurokinin B receptor, NK-2 receptor, NK-2R, seven transmembrane helix receptor, Tachykinin receptor 2
Uniprot ID
Q9UDE7
Mouse ortholog
Tacr2 (21337)
substance-K receptor (P30549)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 48 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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