Sapanisertib
Sapanisertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against serine/threonine-protein kinase mTOR. In addition, it is known to target phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, and phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform.
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Therapeutic Areas
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Trade Name
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EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
45 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 4 | — | — | — | 6 |
| Lung neoplasms | D008175 | C34.90 | 3 | 3 | — | — | — | 5 | |
| Non-small-cell lung carcinoma | D002289 | 4 | 2 | — | — | — | 5 | ||
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 2 | — | — | — | 4 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 2 | — | — | — | 2 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 2 | — | — | — | 2 | |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | 2 | — | — | — | 2 | |
| Multiple myeloma | D009101 | C90.0 | 1 | 1 | — | — | — | 2 | |
| Lymphoma | D008223 | C85.9 | 1 | 2 | — | — | — | 2 | |
| Urinary bladder neoplasms | D001749 | C67 | — | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 7 | — | — | — | — | 7 | |
| Glioblastoma | D005909 | EFO_0000515 | 2 | — | — | — | — | 2 | |
| Hematologic neoplasms | D019337 | 2 | — | — | — | — | 2 | ||
| Cystadenocarcinoma | D003536 | 1 | — | — | — | — | 1 | ||
| Hodgkin disease | D006689 | C81 | 1 | — | — | — | — | 1 | |
| Large-cell lymphoma anaplastic | D017728 | C84.6 | 1 | — | — | — | — | 1 | |
| T-cell lymphoma peripheral | D016411 | C84.9 | 1 | — | — | — | — | 1 | |
| Meningeal neoplasms | D008577 | EFO_0003851 | C70 | 1 | — | — | — | — | 1 |
| Gliosarcoma | D018316 | 1 | — | — | — | — | 1 | ||
| Waldenstrom macroglobulinemia | D008258 | C88.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SAPANISERTIB |
| INN | sapanisertib |
| Description | 5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine is a benzoxazole. |
| Classification | Small molecule |
| Drug class | serine/threonine kinase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2c(N)ncnc21 |
Identifiers
| PDB | — |
| CAS-ID | 1224844-38-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3545097 |
| ChEBI ID | — |
| PubChem CID | 45375953 |
| DrugBank | DB11836 |
| UNII ID | JGH0DF1U03 (ChemIDplus, GSRS) |
Target
Agency Approved
MTOR
MTOR
Organism
Homo sapiens
Gene name
MTOR
Gene synonyms
FRAP, FRAP1, FRAP2, RAFT1, RAPT1
NCBI Gene ID
Protein name
serine/threonine-protein kinase mTOR
Protein synonyms
FK506 binding protein 12-rapamycin associated protein 2, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP-rapamycin associated protein, FKBP12-rapamycin complex-associated protein, FKBP12-rapamycin complex-associated protein 1, Mammalian target of rapamycin, Mechanistic target of rapamycin, mechanistic target of rapamycin (serine/threonine kinase), mTOR, Rapamycin and FKBP12 target 1, rapamycin associated protein FRAP2, Rapamycin target protein 1
Uniprot ID
Mouse ortholog
Mtor (56717)
serine/threonine-protein kinase mTOR (Q9JLN9)
Alternate
PIK3CD
PIK3CD
PIK3CG
PIK3CG
PIK3CA
PIK3CA
Organism
Homo sapiens
Gene name
PIK3CD
Gene synonyms
NCBI Gene ID
Protein name
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Protein synonyms
p110delta, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8/20, phosphoinositide-3-kinase C, phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta, PI3-kinase p110 subunit delta, PI3Kdelta, PtdIns-3-kinase subunit p110-delta
Uniprot ID
Mouse ortholog
Pik3cd (18707)
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Q8CJ28)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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