Salicylic acid
Salicylic acid is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target acid-sensing ion channel 3.
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Commercial
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| derma pella acne care | OTC monograph final | 2023-06-21 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| acne vulgaris | EFO_0003894 | D000152 | L70 |
| psoriasis | EFO_0000676 | D011565 | L40 |
| scalp dermatoses | — | D012536 | — |
| seborrheic dermatitis | — | D012628 | L21 |
| seborrheic keratosis | EFO_0005584 | D017492 | L82 |
| warts | — | D014860 | B07 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D01: Antifungals for dermatological use
— D01A: Antifungals for topical use
— D01AE: Other antifungals for topical use in atc
— D01AE12: Salicylic acid
— D02: Emollients and protectives
— D02A: Emollients and protectives
— D02AF: Salicylic acid emollient and protective preparations
M: Musculo-skeletal system drugs
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AC: Preparations with salicylic acid derivatives, topical for joint and muscle pain
N: Nervous system drugs
— N02: Analgesics
— N02B: Other analgesics and antipyretics in atc
— N02BA: Salicylic acid and derivatives, analgesics and antipyretics
P: Antiparasitic products, insecticides and repellents
— P02: Anthelmintics
— P02D: Anticestodals
— P02DA: Salicylic acid derivative anticestodals
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01B: Antiinflammatory agents, ophthalmologic
— S01BC: Antiinflammatory agents, non-steroidal, ophthalmologic
— S01BC08: Salicylic acid
HCPCS
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Clinical
Clinical Trials
363 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | 1 | 1 | 19 | 21 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 2 | 1 | 8 | 11 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | 1 | 2 | 1 | 7 | 1 | 11 |
| Facial pain | D005157 | R51.9 | 1 | 3 | 1 | 1 | 6 | 10 | |
| Intracranial aneurysm | D002532 | EFO_0003870 | I67.1 | — | — | — | 2 | 4 | 6 |
| Melanosis | D008548 | EFO_0003963 | L81.1 | 1 | — | — | 1 | 1 | 3 |
| Ischemic preconditioning | D019194 | — | — | — | 1 | — | 1 | ||
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | 1 | — | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 1 | — | 1 |
| Seborrheic dermatitis | D012628 | L21 | — | — | — | 1 | — | 1 |
Show 4 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Temporomandibular joint disorders | D013705 | M26.6 | 3 | 3 | 3 | — | 12 | 18 | |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | 1 | 1 | — | 6 | 7 |
| Dental caries | D003731 | EFO_0003819 | K02 | — | 1 | 2 | — | 4 | 6 |
| Psoriasis | D011565 | EFO_0000676 | L40 | — | 2 | 1 | — | 2 | 5 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 1 | 1 | 1 | — | 2 | 4 |
| Postoperative complications | D011183 | — | 1 | 2 | — | 1 | 4 | ||
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | 2 | — | 2 | 4 |
| Pulpitis | D011671 | EFO_1001139 | K04.0 | — | — | 1 | — | 2 | 3 |
| Diaphragmatic hernia | D006548 | EFO_0008561 | K44 | — | 2 | 1 | — | 1 | 3 |
| Infertility | D007246 | EFO_0000545 | — | 1 | 1 | — | 1 | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | I25.1 | — | 1 | — | — | 10 | 11 | |
| Healthy volunteers/patients | — | 5 | 1 | — | — | 4 | 9 | ||
| Diaphragmatic hernias congenital | D065630 | Q79.0 | — | 2 | — | — | 7 | 9 | |
| Sleep bruxism | D020186 | G47.63 | 1 | 1 | — | — | 3 | 5 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | 2 | 3 |
| Pancreatic fistula | D010185 | — | 1 | — | — | 1 | 2 | ||
| Varicose veins | D014648 | HP_0002619 | I83.90 | — | 1 | — | — | 1 | 2 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | 1 | — | — | 1 | 2 |
| Carotid artery diseases | D002340 | EFO_0003781 | — | 1 | — | — | — | 1 | |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amblyopia | D000550 | H53.00 | 1 | — | — | — | 10 | 11 | |
| Peripheral arterial disease | D058729 | EFO_0004265 | 1 | — | — | — | 4 | 5 | |
| Denture stomatitis | D013282 | EFO_1000893 | K12.1 | 1 | — | — | — | 2 | 3 |
| Blood pressure | D001794 | EFO_0004325 | 1 | — | — | — | 1 | 2 | |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | — | — | — | 1 | 2 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | 1 | — | — | — | 1 | 2 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | — | 1 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 1 | — | — | — | — | 1 |
| Chronic disease | D002908 | 1 | — | — | — | — | 1 | ||
| Craniomandibular disorders | D017271 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Esophageal and gastric varices | D004932 | EFO_0009545 | I85 | — | — | — | — | 6 | 6 |
| Myalgia | D063806 | HP_0003326 | M79.1 | — | — | — | — | 4 | 4 |
| Covid-19 | D000086382 | U07.1 | — | — | — | — | 4 | 4 | |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 4 | 4 |
| Leiomyoma | D007889 | HP_0000131 | D25 | — | — | — | — | 4 | 4 |
| Bruxism | D002012 | F45.8 | — | — | — | — | 3 | 3 | |
| Warts | D014860 | B07 | — | — | — | — | 3 | 3 | |
| Thrombosis | D013927 | — | — | — | — | 3 | 3 | ||
| Edentulous jaw | D007575 | — | — | — | — | 3 | 3 | ||
| Septic shock | D012772 | A48.3 | — | — | — | — | 3 | 3 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SALICYLIC ACID |
| INN | — |
| Description | Salicylic acid is a monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves. It has a role as an antiinfective agent, an antifungal agent, a keratolytic drug, an EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor, a plant metabolite, an algal metabolite and a plant hormone. It is a conjugate acid of a salicylate. |
| Classification | Small molecule |
| Drug class | anti-inflammatory agents (salicylic acid derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)c1ccccc1O |
Target
Agency Approved
No data
Alternate
ASIC3
ASIC3
Organism
Homo sapiens
Gene name
ASIC3
Gene synonyms
ACCN3, SLNAC1, TNAC1
NCBI Gene ID
Protein name
acid-sensing ion channel 3
Protein synonyms
acid sensing (proton gated) ion channel 3, Amiloride-sensitive cation channel 3, amiloride-sensitive cation channel 3, testis, hTNaC1, modulatory subunit of ASIC2a, Neuronal amiloride-sensitive cation channel 3, proton-gated cation channel subunit, Testis sodium channel 1
Uniprot ID
Mouse ortholog
Asic3 (171209)
acid-sensing ion channel 3 (Q6X1Y6)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2,485 adverse events reported
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