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Ruboxistaurin
Ruboxistaurin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against protein kinase C beta type. In addition, it is known to target protein kinase C alpha type, protein kinase C gamma type, serine/threonine-protein kinase pim-2, serine/threonine-protein kinase pim-1, and protein kinase C delta type.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
14 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 1 diabetes mellitusD003922EFO_0001359E10—14——4
Diabetic neuropathiesD003929EFO_1000783—13——4
Type 2 diabetes mellitusD003924EFO_0001360E11—13——3
Diabetic retinopathyD003930EFO_0003770——3——3
Diabetes mellitusD003920EFO_0000400E08-E13111——3
Macular edemaD008269——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart failureD006333EFO_0003144I5011———1
Diabetic nephropathiesD003928EFO_0000401—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRUBOXISTAURIN
INNruboxistaurin
Description
Ruboxistaurin (proposed brand name Arxxant) is an investigational drug for diabetic retinopathy being investigated by Eli Lilly and Company. It is a member of the bisindolylmaleimide family.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1
Identifiers
PDB2J2I
CAS-ID169939-94-0
RxCUI394407
ChEMBL IDCHEMBL91829
ChEBI ID—
PubChem CID153999
DrugBankDB11829
UNII ID721809WQCP (ChemIDplus, GSRS)
Target
Agency Approved
PRKCB
PRKCB
Organism
Homo sapiens
Gene name
PRKCB
Gene synonyms
PKCB, PRKCB1
NCBI Gene ID
5579
Protein name
protein kinase C beta type
Protein synonyms
PKC-B, protein kinase C, beta 1 polypeptide
Uniprot ID
P05771
Mouse ortholog
Prkcb (18751)
protein kinase C beta type (P68404)
Alternate
PRKCA
PRKCA
PRKCG
PRKCG
PIM2
PIM2
PIM1
PIM1
PRKCD
PRKCD
Organism
Homo sapiens
Gene name
PRKCA
Gene synonyms
PKCA, PRKACA
NCBI Gene ID
5578
Protein name
protein kinase C alpha type
Protein synonyms
aging-associated gene 6, PKC-A
Uniprot ID
Q96RE4
Mouse ortholog
Prkca (18750)
protein kinase C alpha type (P20444)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 727 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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