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Roxithromycin
Roxithromycin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target motilin receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
gram-negative bacterial infections—D016905—
legionnaires' diseaseEFO_0007343D007877A48.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01F: Macrolides, lincosamides and streptogramins
— J01FA: Macrolides
— J01FA06: Roxithromycin
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bacterial infectionsD001424A49———1—1
Rheumatoid arthritisD001172EFO_0000685M06.9———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Respiratory function testsD012129EFO_0003892——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Reactive arthritisD016918EFO_0007460M02.3————11
AlopeciaD000505HP_0002293L64————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameROXITHROMYCIN
INNroxithromycin
Description
Roxithromycin is semisynthetic derivative of erythromycin A. It has a role as an antibacterial drug. It is an erythromycin derivative, a macrolide and a semisynthetic derivative. It is functionally related to an erythromycin A.
Classification
Small molecule
Drug classantibiotics (Streptomyces strain)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O
Identifiers
PDB1JZZ
CAS-ID80214-83-1
RxCUI9478
ChEMBL IDCHEMBL1214185
ChEBI ID48935
PubChem CID6915744
DrugBankDB00778
UNII ID21KOF230FA (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
MLNR
MLNR
Organism
Homo sapiens
Gene name
MLNR
Gene synonyms
GPR38, MTLR, MTLR1
NCBI Gene ID
2862
Protein name
motilin receptor
Protein synonyms
G protein-coupled receptor 38, G-protein coupled receptor 38
Uniprot ID
O43193
Mouse ortholog
—
—
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,985 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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419 adverse events reported
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