Avandia(rosiglitazone)
Avaglim, Avandamet, Avandaryl, Avandia, Nyracta, Venvia (rosiglitazone) is a small molecule pharmaceutical. Rosiglitazone was first approved as Avandia on 1999-05-25. It is used to treat type 2 diabetes mellitus in the USA. It has been approved in Europe to treat type 2 diabetes mellitus. The pharmaceutical is active against peroxisome proliferator-activated receptor gamma. In addition, it is known to target short transient receptor potential channel 5, transient receptor potential cation channel subfamily M member 3, free fatty acid receptor 1, and retinoic acid receptor RXR-alpha.
Download report
Favorite
Commercial
Trade Name
FDA
EMA
Avandia
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Glimepiride
+
Rosiglitazone maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AVANDARYL | SB Pharmco | N-021700 DISCN | 2005-11-23 | 5 products, RLD |
Hide discontinued
Metformin hydrochloride
+
Rosiglitazone maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AVANDAMET | SB Pharmco | N-021410 DISCN | 2002-10-10 | 5 products, RLD |
Hide discontinued
Rosiglitazone maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AVANDIA | Woodward Pharma Services | N-021071 RX | 1999-05-25 | 2 products, RLD |
Show 1 discontinued
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| type 2 diabetes mellitus | EFO_0001360 | D003924 | E11 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BD: Combinations of oral blood glucose lowering drugs
— A10BD03: Metformin and rosiglitazone
— A10BD04: Glimepiride and rosiglitazone
— A10BG: Thiazolidinediones, blood glucose lowering drugs
— A10BG02: Rosiglitazone
HCPCS
No data
Clinical
Clinical Trials
898 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | G89.18 | 4 | 11 | 31 | 103 | 71 | 218 | |
| Pain | D010146 | EFO_0003843 | R52 | 7 | 6 | 10 | 33 | 27 | 80 |
| Replacement arthroplasty knee | D019645 | 1 | 4 | 2 | 23 | 12 | 40 | ||
| Local anesthesia | D000772 | 2 | 3 | 1 | 10 | 13 | 28 | ||
| Conduction anesthesia | D000765 | — | 1 | 1 | 8 | 13 | 23 | ||
| Nerve block | D009407 | 1 | 1 | — | 10 | 9 | 21 | ||
| Anesthesia | D000758 | 1 | 2 | 4 | 9 | 6 | 20 | ||
| Analgesia | D000698 | — | 3 | 1 | 6 | 9 | 19 | ||
| Acute pain | D059787 | R52 | 2 | 2 | 3 | 5 | 8 | 19 | |
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | — | 6 | 9 | 15 |
Show 114 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Brachial plexus block | D065527 | — | — | 2 | — | 7 | 9 | ||
| Hepatectomy | D006498 | — | — | 1 | — | 5 | 6 | ||
| Spinal anesthesia | D000775 | — | — | 1 | — | 4 | 5 | ||
| Neoplasms | D009369 | C80 | — | 2 | 1 | — | 2 | 5 | |
| Musculoskeletal diseases | D009140 | — | 3 | 2 | — | 1 | 4 | ||
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | 1 | 1 | — | 2 | 3 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | 1 | — | 2 | 3 |
| Knee injuries | D007718 | — | 1 | 1 | — | 1 | 3 | ||
| Sternotomy | D056346 | — | 3 | 1 | — | — | 3 | ||
| Colorectal neoplasms | D015179 | — | — | 1 | — | 2 | 3 |
Show 21 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inguinal hernia | D006552 | HP_0000023 | K40 | 3 | 1 | — | — | 3 | 6 |
| Femoral fractures | D005264 | S72 | — | 1 | — | — | 1 | 2 | |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | 1 | — | — | 1 | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | — | — | 1 | 2 |
| Head and neck neoplasms | D006258 | 1 | 1 | — | — | — | 2 | ||
| Renal colic | D056844 | EFO_1001412 | N23 | — | 1 | — | — | 1 | 2 |
| Bariatric surgery | D050110 | 1 | 1 | — | — | — | 1 | ||
| Chronic bronchitis | D029481 | J42 | — | 1 | — | — | — | 1 | |
| Feeding and eating disorders | D001068 | F50 | — | 1 | — | — | — | 1 | |
| Dentofacial deformities | D063169 | — | 1 | — | — | — | 1 |
Show 11 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 1 | — | — | — | 1 | 2 |
| Plantar fasciitis | D036981 | EFO_1001909 | M72.2 | 1 | — | — | — | — | 1 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | 1 | — | — | — | — | 1 |
| Cleft palate | D002972 | Q35 | 1 | — | — | — | — | 1 | |
| Mouth abnormalities | D009056 | HP_0000153 | Q38.6 | 1 | — | — | — | — | 1 |
| Topical administration | D000287 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Arteriovenous fistula | D001164 | Q27.3 | — | — | — | — | 2 | 2 | |
| Acrodynia | D000170 | EFO_1001756 | — | — | — | — | 2 | 2 | |
| Epidural analgesia | D015360 | — | — | — | — | 2 | 2 | ||
| Female genital diseases | D005831 | EFO_0009549 | N85 | — | — | — | — | 2 | 2 |
| Horner syndrome | D006732 | G90.2 | — | — | — | — | 2 | 2 | |
| Meningioma | D008579 | EFO_0003098 | D32.9 | — | — | — | — | 2 | 2 |
| Complex regional pain syndromes | D020918 | EFO_1001998 | — | — | — | — | 2 | 2 | |
| Overweight | D050177 | E66.3 | — | — | — | — | 2 | 2 | |
| Orchiopexy | D056126 | — | — | — | — | 2 | 2 | ||
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | — | — | 2 | 2 |
Show 68 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | ROSIGLITAZONE |
| INN | rosiglitazone |
| Description | Rosiglitazone is an aminopyridine and a member of thiazolidinediones. It has a role as an insulin-sensitizing drug, a ferroptosis inhibitor and an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor. It is a conjugate acid of a rosiglitazone(1-). |
| Classification | Small molecule |
| Drug class | peroxisome proliferator activiating receptor (PPAR) agonists (thiazolidene derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1 |
Target
Agency Approved
PPARG
PPARG
Organism
Homo sapiens
Gene name
PPARG
Gene synonyms
NR1C3
NCBI Gene ID
Protein name
peroxisome proliferator-activated receptor gamma
Protein synonyms
Nuclear receptor subfamily 1 group C member 3, peroxisome proliferator-activated receptor-gamma 5, peroxisome proliferator-activated receptor-gamma splicing, PPAR-gamma
Uniprot ID
Mouse ortholog
Pparg (19016)
peroxisome proliferator-activated receptor gamma (P37238)
Alternate
TRPC5
TRPC5
TRPM3
TRPM3
FFAR1
FFAR1
RXRA
RXRA
Organism
Homo sapiens
Gene name
TRPC5
Gene synonyms
TRP5
NCBI Gene ID
Protein name
short transient receptor potential channel 5
Protein synonyms
hTRP-5, hTRP5, protein phosphatase 1, regulatory subunit 159, transient receptor potential channel 5, Transient receptor protein 5, TRP-5
Uniprot ID
Mouse ortholog
Trpc5 (22067)
short transient receptor potential channel 5 (Q9R0D4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 26,461 documents
View more details
Safety
Black-box Warning
Black-box warning for: Avandamet
, Avandia
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
2,673 adverse events reported
View more details
Premium feature
Learn more about premium features at pharmakb.com
Learn more