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Rontalizumab
Rontalizumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. It is known to target interferon alpha-17, interferon alpha-16, interferon alpha-10, interferon alpha-14, interferon alpha-5, interferon alpha-2, interferon alpha-4, interferon alpha-1/13, interferon alpha-7, interferon alpha-6, interferon alpha-8, and interferon alpha-21.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Systemic lupus erythematosusD008180EFO_0002690M3211———2
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRONTALIZUMAB
INNrontalizumab
Description
Rontalizumab (humanized mab)
Classification
Antibody
Drug classmonoclonal antibodies
Image (chem structure or protein)RONTALIZUMAB
Structure (InChI/SMILES or Protein Sequence)
>4Z5R:J,L,V,P,R,T,Y,A|anti-IFN-a antibody rontalizumab light chain DIQMTQSPSSLSASVGDRVTITCRASQSVSTSSYSYMHWYQQKPGKAPKVLISYASNLESGVPSRFSGSGSGTDFTLTIS SLQPEDFATYYCQHSWGIPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQS GNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC >4Z5R:K,M,W,Q,S,U,Z,B|anti-IFN-a antibody rontalizumab heavy chain modules VH and CH1 (Fab) EVQLVESGGGLVQPGGSLRLSCATSGYTFTEYIIHWVRQAPGKGLEWVASINPDYDITNYNQRFKGRFTISLDKSKRTAY LQMNSLRAEDTAVYYCASWISDFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNS GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT
Identifiers
PDB4Z5R
CAS-ID948570-30-7
RxCUI—
ChEMBL IDCHEMBL1743066
ChEBI ID—
PubChem CID—
DrugBankDB12844
UNII IDLDO2FIQ61I (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
IFNA17
IFNA17
IFNA16
IFNA16
IFNA10
IFNA10
IFNA14
IFNA14
IFNA5
IFNA5
IFNA2
IFNA2
IFNA4
IFNA4
IFNA1
IFNA1
IFNA7
IFNA7
IFNA6
IFNA6
IFNA8
IFNA8
IFNA21
IFNA21
Organism
Homo sapiens
Gene name
IFNA17
Gene synonyms
NCBI Gene ID
3451
Protein name
interferon alpha-17
Protein synonyms
IFN-alpha-17, Interferon alpha-88, Interferon alpha-I', Interferon alpha-T, interferon alpha-WA, LeIF I
Uniprot ID
Q7M4Q4
Mouse ortholog
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Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 225 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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