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Rolofylline
Rolofylline is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target adenosine receptor A3, adenosine receptor A2a, adenosine receptor A2b, and adenosine receptor A1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart failureD006333EFO_0003144I50—33——6
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Renal insufficiencyD051437HP_0000083N19—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameROLOFYLLINE
INNrolofylline
Description
Rolofylline is an oxopurine.
Classification
Small molecule
Drug classtheophylline derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCn1c(=O)c2nc(C34CC5CC(CC3C5)C4)[nH]c2n(CCC)c1=O
Identifiers
PDB—
CAS-ID136199-02-5
RxCUI—
ChEMBL IDCHEMBL52333
ChEBI ID—
PubChem CID64627
DrugBankDB12670
UNII ID7805S5HIHX (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADORA3
ADORA3
ADORA2A
ADORA2A
ADORA2B
ADORA2B
ADORA1
ADORA1
Organism
Homo sapiens
Gene name
ADORA3
Gene synonyms
NCBI Gene ID
140
Protein name
adenosine receptor A3
Protein synonyms
Uniprot ID
Q9BYZ1
Mouse ortholog
—
—
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 281 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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