Rocuronium bromide
Zemuron (rocuronium bromide) is a small molecule pharmaceutical. Rocuronium bromide was first approved as Zemuron on 1994-03-17.
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Rocuronium bromide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZEMURON | Organon | N-020214 DISCN | 1994-03-17 | 3 products, RLD |
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Brand Name | Status | Last Update |
|---|---|---|
| rocuronium bromide | ANDA | 2023-05-09 |
Indications
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Agency Specific
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Clinical
Clinical Trials
218 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuromuscular blockade | D019148 | — | 5 | 2 | 17 | 21 | 45 | ||
| Anesthesia | D000758 | — | 1 | 7 | 8 | 11 | 27 | ||
| General anesthesia | D000768 | — | 3 | 7 | 2 | 7 | 19 | ||
| Muscle relaxation | D009126 | — | 1 | 2 | 5 | 1 | 9 | ||
| Postoperative pain | D010149 | G89.18 | — | — | 1 | 3 | 3 | 7 | |
| Laparoscopy | D010535 | — | — | — | 4 | 2 | 6 | ||
| Muscle weakness | D018908 | HP_0001324 | — | — | 1 | 2 | 1 | 4 | |
| Delayed emergence from anesthesia | D055191 | — | — | — | 3 | 1 | 4 | ||
| Morbid obesity | D009767 | EFO_0001074 | — | — | — | 2 | 2 | 4 | |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | 1 | 3 | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart arrest | D006323 | EFO_0009492 | I46 | — | 1 | 1 | — | 1 | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | 1 | — | — | 1 |
| Lung neoplasms | D008175 | C34.90 | — | 1 | 1 | — | — | 1 | |
| Nerve block | D009407 | — | — | 1 | — | — | 1 | ||
| Back pain | D001416 | HP_0003418 | M54 | — | — | 1 | — | — | 1 |
| Local anesthesia | D000772 | — | — | 1 | — | — | 1 | ||
| Spinal fusion | D013123 | — | — | 1 | — | — | 1 | ||
| Organophosphate poisoning | D062025 | — | 1 | 1 | — | — | 1 | ||
| Muscle fatigue | D018763 | — | — | 1 | — | — | 1 | ||
| Hypothermia | D007035 | HP_0002045 | T68 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 1 | — | — | — | 1 |
| Out-of-hospital cardiac arrest | D058687 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Delirium | D003693 | R41.0 | 1 | — | — | — | 2 | 3 | |
| High-frequency jet ventilation | D006611 | 1 | — | — | — | — | 1 | ||
| Spinal fractures | D016103 | EFO_0003902 | S12 | 1 | — | — | — | — | 1 |
| Spinal stenosis | D013130 | EFO_0007490 | M48.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharyngitis | D010612 | R07.0 | — | — | — | — | 3 | 3 | |
| Critical illness | D016638 | — | — | — | — | 2 | 2 | ||
| Patient satisfaction | D017060 | — | — | — | — | 2 | 2 | ||
| Neuromuscular monitoring | D061886 | — | — | — | — | 2 | 2 | ||
| Strabismus | D013285 | HP_0000486 | H50.2 | — | — | — | — | 1 | 1 |
| Melanoma | D008545 | — | — | — | — | 1 | 1 | ||
| Colorectal neoplasms | D015179 | — | — | — | — | 1 | 1 | ||
| Fasciculation | D005207 | R25.3 | — | — | — | — | 1 | 1 | |
| Pneumothorax | D011030 | J93.11 | — | — | — | — | 1 | 1 | |
| Bronchoscopy | D001999 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ROCURONIUM BROMIDE |
| INN | rocuronium bromide |
| Description | Rocuronium bromide is the organic bromide salt of a 5alpha androstane compound having 3alpha-hydroxy-, 17beta-acetoxy-, 2beta-morpholino- and 16beta-N-allyllyrrolidinium substituents. It has a role as a neuromuscular agent and a muscle relaxant. It is an organic bromide salt and a quaternary ammonium salt. It contains a rocuronium. It derives from a hydride of a 5alpha-androstane. |
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives: neuromuscular blocking agents; quaternary ammonium derivatives: neuromuscular blocking agents |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1.[Br-] |
Identifiers
| PDB | — |
| CAS-ID | 119302-91-9 |
| RxCUI | 32521 |
| ChEMBL ID | CHEMBL1200648 |
| ChEBI ID | 8885 |
| PubChem CID | 441351 |
| DrugBank | DB00728 |
| UNII ID | I65MW4OFHZ (ChemIDplus, GSRS) |
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5,365 adverse events reported
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