Skip to content
Norvir(ritonavir)
Kaletra, Norvir, Paxlovid, Technivie, Viekira, Viekirax (ritonavir) is a small molecule pharmaceutical. Ritonavir was first approved as Norvir on 1996-03-01. It is used to treat acquired immunodeficiency syndrome in the USA. It has been approved in Europe to treat chronic hepatitis c, dna virus infections, and HIV infections. It is known to target cytochrome P450 3A5, cytochrome P450 3A4, and UDP-glucuronosyltransferase 1A1.
Download report
Favorite
COVID-19
Case Study: COVID-19
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
urogenital diseasesD000091642
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Norvir (generic drugs available since 2015-01-15)
Combinations
Kaletra (generic drugs available since 2015-01-15, discontinued: Technivie, Viekira)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dasabuvir sodium
+
Ombitasvir
+
Paritaprevir
+
Ritonavir
Tradename
Company
Number
Date
Products
VIEKIRA PAK (COPACKAGED)AbbVieN-206619 DISCN2014-12-19
1 products, RLD
VIEKIRA XRAbbVieN-208624 DISCN2016-07-22
1 products, RLD
Hide discontinued
Lopinavir
+
Ritonavir
Tradename
Company
Number
Date
Products
KALETRAAbbVieN-021251 RX2000-09-15
1 products, RLD, RS
KALETRAAbbVieN-021906 RX2005-10-28
2 products, RLD, RS
Show 1 discontinued
Ombitasvir
+
Paritaprevir
+
Ritonavir
Tradename
Company
Number
Date
Products
TECHNIVIEAbbVieN-207931 DISCN2015-07-24
1 products, RLD
Hide discontinued
Ritonavir
Tradename
Company
Number
Date
Products
NORVIRAbbVieN-022417 RX2010-02-10
1 products, RLD, RS
NORVIRAbbVieN-209512 RX2017-06-07
1 products, RLD, RS
Show 3 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
kaletraNew Drug Application2020-10-01
norvirNew Drug Application2020-10-28
paxlovidUse Authorization2021-12-23
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acquired immunodeficiency syndromeEFO_0000765D000163B20
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Dasabuvir Sodium / Ombitasvir / Paritaprevir / Ritonavir, Viekira Xr, Abbvie
93332042035-01-02DPU-1889
97441702035-01-02DPU-1889
101053652035-01-02DPU-1889
102015412032-05-17DP
102015842032-05-17U-1889
Dasabuvir Sodium / Ombitasvir / Paritaprevir / Ritonavir, Viekira Pak (Copackaged), Abbvie
96298412033-10-18DPU-1753
102015422033-10-18DPU-1753
84661592032-09-04U-1637
84923862032-09-04U-1840
86801062032-09-04U-1637
86859842032-09-04U-1840
86919382032-04-13DS, DP
86860262031-06-09DP
84205962031-04-10DS, DP
90444802031-04-10U-1638
90063872030-06-10U-1687
86425382029-09-10DS, DPU-1638
81881042029-05-17DS, DPU-1636
85012382028-12-19DS, DPU-1636
91395362028-11-09U-1753
82683492024-08-25DP
83990152024-08-25DP
ATC Codes
J: Antiinfectives for systemic use
J05: Antivirals for systemic use
J05A: Direct acting antivirals
J05AE: Protease inhibitors, direct acting antivirals
J05AE03: Ritonavir
J05AP: Antivirals for treatment of hcv infections
J05AP52: Dasabuvir, ombitasvir, paritaprevir and ritonavir
J05AP53: Ombitasvir, paritaprevir and ritonavir
J05AR: Antivirals for treatment of hiv infections, combinations
J05AR10: Lopinavir and ritonavir
J05AR23: Atazanavir and ritonavir
J05AR26: Darunavir and ritonavir
HCPCS
No data
Clinical
Clinical Trials
788 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B2064101817160357
Healthy volunteers/patients8526396
HivD006678O98.71581624766
Covid-19D000086382U07.1725188857
Chronic hepatitis cD019698EFO_0004220B18.231884639
Hepatitis cD006526B19.2131172333
InfectionsD007239EFO_00005441087227
Hiv-1D015497144514
Acquired immunodeficiency syndromeD000163EFO_0000765B202128114
TuberculosisD014376EFO_0000774A15-A19343312
Show 28 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic hepatitis bD019694EFO_0004197B18.1195114
MalariaD008288EFO_0001068B54426
Liver cirrhosisD008103EFO_0001422K74.01315
Respiratory distress syndromeD012128EFO_1000637J8013114
Chronic hepatitis dD019701213
Renal insufficiencyD051437HP_0000083N19112
HepatitisD006505HP_0012115K75.9111
FibrosisD00535511
Breast feedingD00194211
Virus diseasesD014777B3411
Show 3 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GlioblastomaD005909EFO_0000515122
Drug-related side effects and adverse reactionsD064420T88.71112
Chronic hepatitisD006521K73.922
Hepatitis dD003699EFO_000730422
DiseaseD004194EFO_0000408R6911
ParasitemiaD018512111
NeoplasmsD009369C8011
SarcomaD01250911
Mycobacterium avium-intracellulare infectionD015270EFO_000738611
Liver diseasesD008107EFO_0001421K70-K7711
Show 11 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatic insufficiencyD04855044
Biological availabilityD00168244
PharmacokineticsD01059922
Pulmonary arterial hypertensionD00008102922
Substance-related disordersD019966EFO_0003890F1311
Opioid-related disordersD009293EFO_0005611F1111
Insulin resistanceD007333EFO_000261411
HypertensionD006973EFO_0000537I1011
Therapeutic equivalencyD01381011
Multiple myelomaD009101C90.011
Show 18 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Viral pneumoniaD011024EFO_0007541J12.922
Wasting syndromeD019282R6411
Cytokine release syndromeD000080424D89.8311
Neurobehavioral manifestationsD019954EFO_000436411
Medication adherenceD055118EFO_000634411
Child behaviorD00265211
Biliary liver cirrhosisD008105K74.311
CoronavirusD01793411
Hodgkin diseaseD006689C8111
Retinal diseasesD012164HP_0000479H35.911
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameRITONAVIR
INNritonavir
Description
Ritonavir is an L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver. It has a role as an antiviral drug, a HIV protease inhibitor, an environmental contaminant and a xenobiotic. It is a member of 1,3-thiazoles, a L-valine derivative, a carbamate ester, a member of ureas and a carboxamide.
Classification
Small molecule
Drug classantivirals: HIV protease inhibitors (saquinavir type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1
Identifiers
PDB5VEU
CAS-ID155213-67-5
RxCUI85762
ChEMBL IDCHEMBL163
ChEBI ID45409
PubChem CID392622
DrugBankDB00503
UNII IDO3J8G9O825 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CYP3A5
CYP3A5
CYP3A4
CYP3A4
UGT1A1
UGT1A1
Organism
Homo sapiens
Gene name
CYP3A5
Gene synonyms
NCBI Gene ID
Protein name
cytochrome P450 3A5
Protein synonyms
aryl hydrocarbon hydroxylase, CYPIIIA5, cytochrome P450 HLp2, cytochrome P450, family 3, subfamily A, polypeptide 5, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5, Cytochrome P450-PCN3, flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase
Uniprot ID
Mouse ortholog
Variants
Clinical Variant
No data
Financial
Viekira - AbbVie
$
£
Mock data
Subscribe for the real data
Mock data
Subscribe for the real data
Paxlovid - Pfizer
$
£
Mock data
Subscribe for the real data
Mock data
Subscribe for the real data
Norvir - AbbVie
$
£
Mock data
Subscribe for the real data
Mock data
Subscribe for the real data
Kaletra - AbbVie
$
£
Mock data
Subscribe for the real data
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 36,301 documents
View more details
Safety
Black-box Warning
Black-box warning for: Norvir
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
474 adverse events reported
View more details