Rimabotulinumtoxinb
Myobloc (rimabotulinumtoxinb) is an unknown pharmaceutical. Rimabotulinumtoxinb was first approved as Myobloc on 2000-12-08. It is used to treat dystonia and neck pain in the USA.
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Commercial
Trade Name
FDA
EMA
Myobloc
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Rimabotulinumtoxinb
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Myobloc | rimabotulinumtoxinB | Solstice NeuroSciences | N-103846 RX | 2000-12-08 | 3 products |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| myobloc | Biologic Licensing Application | 2021-03-22 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| dystonia | HP_0001332 | D004421 | G24 |
| neck pain | HP_0030833 | D019547 | M54.2 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
rimabotulinumtoxinb, Myobloc, Solstice NeuroSciences, LLC | |||
| 2107-12-08 | Orphan excl. | ||
Patent Expiration
No data
ATC Codes
No data
HCPCS
Code | Description |
|---|---|
| J0587 | Injection, rimabotulinumtoxinb, 100 units |
Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv | D006678 | O98.7 | — | — | 1 | — | — | 1 | |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gastrointestinal diseases | D005767 | — | 1 | — | — | — | 1 | ||
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | — | — | — | 1 |
| Hepatic encephalopathy | D006501 | K72.91 | — | 1 | — | — | — | 1 | |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | RIMABOTULINUMTOXINB |
| INN | — |
| Description | Botulinum toxin, or botulinum neurotoxin (BoNT), is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. It is also known as Botulin, the density of which is predicted to be 1.5±0.1 g/cm3.
It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis. The toxin causes the disease botulism. The toxin is also used commercially for medical and cosmetic purposes.
|
| Classification | Neurotoxin |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108710 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00083 |
| UNII ID | — |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Myobloc - Supernus Pharmaceuticals
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 430 documents
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Safety
Black-box Warning
Black-box warning for: Myobloc
Adverse Events
Top Adverse Reactions
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168 adverse events reported
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