Rilotumumab
Rilotumumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against hepatocyte growth factor.
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Therapeutic Areas
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Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 2 | 1 | 2 | — | — | 4 |
| Squamous cell carcinoma | D002294 | — | 1 | 1 | — | 1 | 2 | ||
| Squamous cell neoplasms | D018307 | — | 1 | 1 | — | 1 | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 3 | 3 | — | — | — | 4 | |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | — | — | — | 1 | |
| Gliosarcoma | D018316 | — | 1 | — | — | — | 1 | ||
| Esophageal neoplasms | D004938 | C15 | 1 | 1 | — | — | — | 1 | |
| Non-small-cell lung carcinoma | D002289 | 1 | 1 | — | — | — | 1 | ||
| Colorectal neoplasms | D015179 | 1 | 1 | — | — | — | 1 | ||
| Gastrointestinal neoplasms | D005770 | C26.9 | 1 | 1 | — | — | — | 1 | |
| Colonic neoplasms | D003110 | C18 | 1 | 1 | — | — | — | 1 | |
| Rectal neoplasms | D012004 | 1 | 1 | — | — | — | 1 | ||
| Malignant mesothelioma | D000086002 | — | 1 | — | — | — | 1 |
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | RILOTUMUMAB |
| INN | rilotumumab |
| Description | Rilotumumab (human mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 872514-65-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743063 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11972 |
| UNII ID | 51WEW898IJ (ChemIDplus, GSRS) |
Target
Agency Approved
HGF
HGF
Organism
Homo sapiens
Gene name
HGF
Gene synonyms
HPTA
NCBI Gene ID
Protein name
hepatocyte growth factor
Protein synonyms
fibroblast-derived tumor cytotoxic factor, hepatocyte growth factor (hepapoietin A; scatter factor), Hepatopoietin-A, lung fibroblast-derived mitogen, Scatter factor, SF
Uniprot ID
Mouse ortholog
Hgf (15234)
hepatocyte growth factor (Q6LBE6)
Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 693 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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22 adverse events reported
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