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Rifapentine
Priftin (rifapentine) is a small molecule pharmaceutical. Rifapentine was first approved as Priftin on 1998-06-22. It is used to treat latent tuberculosis, mycobacterium infections, and pulmonary tuberculosis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
Trade Name
FDA
EMA
Priftin
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Rifapentine
Tradename
Company
Number
Date
Products
PRIFTINSanofiN-021024 RX1998-06-22
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
priftinNew Drug Application2023-06-06
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
latent tuberculosis—D055985Z22.7
mycobacterium infections—D009164A31.9
pulmonary tuberculosisEFO_1000049D014397A15
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AB: Antibiotics, antitubercular
— J04AB05: Rifapentine
HCPCS
No data
Clinical
Clinical Trials
62 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B208753830
TuberculosisD014376EFO_0000774A15-A193811416
Mycobacterium avium-intracellulare infectionD015270EFO_0007386—141511
InfectionsD007239EFO_00005443—12—6
Mycobacterium avium complexD0152691——1—2
Crohn diseaseD003424EFO_0000384K50——11—2
Drug interactionsD004347———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MycosesD009181B35-B491—1——2
Lung diseasesD008171EFO_0003818J98.4—11——1
Helicobacter infectionsD016481EFO_1000961——1——1
GastritisD005756EFO_0000217K29.7——1——1
Nontuberculous mycobacterium infectionsD009165EFO_0007461A31.9——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HivD006678O98.712———3
Pulmonary tuberculosisD014397EFO_1000049A15—1——12
Coronary diseaseD003327—1———1
Chlamydophila infectionsD023521EFO_1000863—1———1
Staphylococcus aureusD013211NCBITaxon_1280—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—4————4
Opioid-related disordersD009293EFO_0005611F111————1
Bacterial infectionsD001424A491————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acquired immunodeficiency syndromeD000163EFO_0000765B20————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRIFAPENTINE
INNrifapentine
Description
Rifapentine, sold under the brand name Priftin, is an antibiotic used in the treatment of tuberculosis. In active tuberculosis it is used together with other antituberculosis medications. In latent tuberculosis it is typically used with isoniazid. It is taken by mouth.
Classification
Small molecule
Drug classantibiotics (rifamycin derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C6CCCC6)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C
Identifiers
PDB—
CAS-ID61379-65-5
RxCUI35617
ChEMBL IDCHEMBL1660
ChEBI ID45304
PubChem CID5462354
DrugBankDB01201
UNII IDXJM390A33U (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,795 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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1,405 adverse events reported
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