Ravuconazole
Ravuconazole is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Indications
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Agency Specific
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Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | C95 | 1 | 1 | — | — | — | 1 | |
| Myelodysplastic syndromes | D009190 | D46 | 1 | 1 | — | — | — | 1 | |
| Infections | D007239 | EFO_0000544 | 1 | 1 | — | — | — | 1 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | 1 | — | — | — | 1 |
| Myeloproliferative disorders | D009196 | D47.1 | 1 | 1 | — | — | — | 1 | |
| Lymphoma | D008223 | C85.9 | 1 | 1 | — | — | — | 1 | |
| Neuroblastoma | D009447 | EFO_0000621 | 1 | 1 | — | — | — | 1 | |
| Plasma cell neoplasms | D054219 | 1 | 1 | — | — | — | 1 | ||
| Trophoblastic neoplasms | D014328 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | RAVUCONAZOLE |
| INN | ravuconazole |
| Description | Ravuconazole is a member of the class of triazoles that is 1-butyl-1H-1,2,4-triazole in which the butyl group is substituted at positions 2, 2, and 3 by hydroxy, 2,4-difluorophenyl, and 4-(p-cyanophenyl)-1,3-thiazol-2-yl groups, respectively (the R,R stereoisomer). It exhibits antifungal activity by inhibition of 14alpha demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal cell wall and fungal cell death. (NCIO4) It has a role as an ergosterol biosynthesis inhibitor, an antifungal drug, an EC 1.14.14.154 (sterol 14alpha-demethylase) inhibitor and an antileishmanial agent. It is a member of triazoles, a member of fluorobenzenes, a tertiary alcohol, a member of 1,3-thiazoles and a nitrile. |
| Classification | Small molecule |
| Drug class | systemic antifungals (miconazole type) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](c1nc(-c2ccc(C#N)cc2)cs1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F |
Identifiers
| PDB | — |
| CAS-ID | 182760-06-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL294029 |
| ChEBI ID | — |
| PubChem CID | 467825 |
| DrugBank | DB06440 |
| UNII ID | 95YH599JWV (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
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Safety
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Adverse Events
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1 adverse events reported
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