Radotinib
Radotinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Therapeutic Areas
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Trade Name
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Indications
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Agency Specific
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | 1 | 2 | 1 | — | 1 | 4 | |
| Philadelphia chromosome | D010677 | 1 | 1 | 2 | — | — | 3 | ||
| Leukemia | D007938 | C95 | 1 | 1 | 1 | — | — | 2 | |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 1 | 1 | 1 | — | — | 2 |
| Myeloid leukemia | D007951 | C92 | 1 | 1 | 1 | — | — | 2 | |
| Myeloid leukemia chronic-phase | D015466 | — | — | 2 | — | — | 2 | ||
| Bone marrow diseases | D001855 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | RADOTINIB |
| INN | radotinib |
| Description | Radotinib (INN; trade name Supect), and sometimes referred to by its investigational name IY5511, is a drug for the treatment of different types of cancer, most notably Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) with resistance or intolerance of other Bcr-Abl tyrosine-kinase inhibitors, such as patients resistant or intolerant to imatinib.
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| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cnccn5)n4)c3)cc(C(F)(F)F)c2)cn1 |
Identifiers
| PDB | — |
| CAS-ID | 926037-48-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297524 |
| ChEBI ID | — |
| PubChem CID | 16063245 |
| DrugBank | DB12323 |
| UNII ID | I284LJY110 (ChemIDplus, GSRS) |
Target
Agency Approved
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Variants
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Additional graphs summarizing 189 documents
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Safety
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Adverse Events
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3 adverse events reported
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