Pyridoxine
Berocca Pn, Bonjesta, Diclegis, Hexa-betalin, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Tpn, Vitaped (pyridoxine) is a small molecule pharmaceutical. Pyridoxine was first approved as Bendectin on 1982-01-01. It is used to treat seizures and vitamin b 6 deficiency in the USA.
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Commercial
Trade Name
FDA
EMA
Combinations
Bonjesta, Diclegis, Infuvite (generic drugs available since 1982-01-01, discontinued: Bendectin, Berocca pn, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Tpn, Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alpha-tocopherol acetate
+
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin k
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| INFUVITE ADULT | Sandoz | N-021163 RX | 2000-05-18 | 2 products, RLD, RS |
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| M.V.I. PEDIATRIC | Hospira | N-018920 DISCN | 2000-09-21 | 1 products, RLD |
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin 5'-phosphate sodium
+
Thiamine
+
Vitamin a
+
Vitamin e
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| M.V.I.-12 LYOPHILIZED | Teligent | N-018933 DISCN | 1985-08-08 | 1 products |
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| M.V.I.-12 ADULT | Hospira | N-008809 DISCN | 2004-04-22 | 1 products |
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
+
Vitamin k
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin e
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BEROCCA PN | Roche | N-006071 DISCN | 1985-10-10 | 1 products |
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VITAPED | Hospira | N-020176 DISCN | 1993-12-29 | 1 products |
Hide discontinued
Doxylamine succinate
+
Pyridoxine hydrochloride
Niacinamide
+
Pyridoxine hydrochloride
+
Tyrosine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TPN | International Minerals | N-008378 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| adult infuvite multiple vitamins | New Drug Application | 2016-10-28 |
| bonjesta | New Drug Application | 2021-12-21 |
| diclegis | New Drug Application | 2021-12-17 |
| doxylamine succinate and pyridoxine hydrochloride | NDA authorized generic | 2023-06-15 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| seizures | HP_0007359 | D012640 | G40.4 |
| vitamin b 6 deficiency | — | D026681 | E53.1 |
Agency Specific
FDA
EMA
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11H: Other plain vitamin preparations in atc
— A11HA: Other plain vitamin preparations in atc
— A11HA02: Pyridoxine (vit b6)
J: Antiinfectives for systemic use
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AM: Combinations of drugs for treatment of tuberculosis
— J04AM08: Isoniazid, sulfamethoxazole, trimethoprim and pyridoxine
HCPCS
Code | Description |
|---|---|
| J3415 | Injection, pyridoxine hcl, 100 mg |
Clinical
Clinical Trials
30 clinical trials
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | U07.1 | — | 1 | 1 | — | — | 1 | |
| Sars-cov-2 | D000086402 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Orthostatic hypotension | D007024 | I95.1 | 1 | 3 | — | — | — | 4 | |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 2 | 1 | — | — | 1 | 3 |
| Spinal muscular atrophies of childhood | D014897 | Orphanet_83419 | G12.0 | — | 2 | — | — | — | 2 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 2 | — | — | — | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 2 | — | — | — | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 2 | — | — | — | 2 |
| Constipation | D003248 | HP_0002019 | K59.0 | 1 | 2 | — | — | — | 2 |
| Spinal muscular atrophy | D009134 | EFO_0008525 | G12.1 | — | 1 | — | — | — | 1 |
| Chronic fatigue syndrome | D015673 | EFO_0004540 | G93.31 | — | 1 | — | — | — | 1 |
| Primary dysautonomias | D054969 | — | 1 | — | — | — | 1 |
Show 11 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pure autonomic failure | D054970 | 1 | — | — | — | — | 1 | ||
| Orthostatic intolerance | D054971 | 1 | — | — | — | — | 1 | ||
| Glycogen storage disease type ii | D006009 | Orphanet_365 | E74.02 | 1 | — | — | — | — | 1 |
| Job syndrome | D007589 | EFO_0003775 | D82.4 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | — | — | 1 | 1 | |
| Diabetes complications | D048909 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PYRIDOXINE |
| INN | pyridoxine |
| Description | Pyridoxine is a hydroxymethylpyridine with hydroxymethyl groups at positions 4 and 5, a hydroxy group at position 3 and a methyl group at position 2. The 4-methanol form of vitamin B6, it is converted intoto pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid. It has a role as a cofactor, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a monohydroxypyridine, a vitamin B6, a member of methylpyridines and a hydroxymethylpyridine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ncc(CO)c(CO)c1O |
Identifiers
| PDB | — |
| CAS-ID | 65-23-6 |
| RxCUI | 684879 |
| ChEMBL ID | CHEMBL1364 |
| ChEBI ID | 16709 |
| PubChem CID | 1054 |
| DrugBank | DB00165 |
| UNII ID | KV2JZ1BI6Z (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,334 adverse events reported
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