Propofol
Diprivan (propofol) is a small molecule pharmaceutical. Propofol was first approved as Diprivan on 1989-10-02. It is used to treat delirium, pain, psychomotor agitation, and status epilepticus in the USA. It is known to target potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1.
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Commercial
Trade Name
FDA
EMA
Diprivan (generic drugs available since 1999-01-04)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Propofol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DIPRIVAN | Fresenius Kabi | N-019627 RX | 1996-06-11 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| diprivan | New Drug Application | 2023-04-28 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| delirium | — | D003693 | R41.0 |
| pain | EFO_0003843 | D010146 | R52 |
| psychomotor agitation | — | D011595 | — |
| status epilepticus | EFO_0008526 | D013226 | G41 |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Propofol, Diprivan, Fresenius Kabi Usa | |||
| 8476010 | 2024-12-01 | DS, DP | |
HCPCS
Code | Description |
|---|---|
| J2704 | Injection, propofol, 10 mg |
Clinical
Clinical Trials
1122 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anesthesia | D000758 | 9 | 5 | 12 | 42 | 65 | 131 | ||
| General anesthesia | D000768 | 5 | 2 | 8 | 13 | 20 | 48 | ||
| Delirium | D003693 | R41.0 | 1 | 1 | 1 | 18 | 17 | 38 | |
| Postoperative pain | D010149 | G89.18 | 2 | 1 | 3 | 10 | 13 | 28 | |
| Pain | D010146 | EFO_0003843 | R52 | 2 | 1 | 2 | 10 | 12 | 26 |
| Healthy volunteers/patients | — | 4 | — | — | 11 | 6 | 21 | ||
| Postoperative cognitive complications | D000079690 | — | — | 1 | 5 | 6 | 12 | ||
| Emergence delirium | D000071257 | 2 | — | 1 | 4 | 4 | 11 | ||
| Neoplasms | D009369 | C80 | — | 1 | 2 | 4 | 3 | 10 | |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | 1 | 5 | 3 | 10 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Intraoperative awareness | D058926 | — | 2 | 1 | — | 4 | 7 | ||
| Coronary artery bypass | D001026 | EFO_0003776 | — | 2 | 1 | — | 1 | 4 | |
| Premedication | D011292 | — | 2 | 2 | — | 1 | 3 | ||
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | 1 | — | 2 | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | 1 | — | 1 | 2 |
| Abscess | D000038 | EFO_0003030 | — | — | 1 | — | 1 | 2 | |
| Wounds and injuries | D014947 | T14.8 | — | 1 | 1 | — | 1 | 2 | |
| Craniotomy | D003399 | — | — | 1 | — | 1 | 2 | ||
| Leukemia | D007938 | C95 | — | 1 | 1 | — | 1 | 2 | |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | 1 | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Strabismus | D013285 | HP_0000486 | H50.2 | — | 1 | — | — | 2 | 3 |
| Lung injury | D055370 | S27.30 | 1 | 1 | — | — | 1 | 2 | |
| Circulating neoplastic cells | D009360 | — | 1 | — | — | 1 | 2 | ||
| Reperfusion injury | D015427 | 1 | 1 | — | — | 1 | 2 | ||
| Radical mastectomy | D015409 | 1 | 1 | — | — | — | 1 | ||
| Tonsillitis | D014069 | HP_0011110 | J03 | — | 1 | — | — | — | 1 |
| Headache disorders | D020773 | EFO_0009550 | G44 | — | 1 | — | — | — | 1 |
| Secondary headache disorders | D051271 | — | 1 | — | — | — | 1 | ||
| Airway remodeling | D056151 | — | 1 | — | — | — | 1 | ||
| Brain injuries | D001930 | S06.9 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | — | — | — | 2 | 3 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | 1 | 2 |
| Pruritus | D011537 | HP_0000989 | L29 | 1 | — | — | — | — | 1 |
| Femur head necrosis | D005271 | 1 | — | — | — | — | 1 | ||
| Vital signs | D055986 | EFO_0004303 | 1 | — | — | — | — | 1 | |
| Scoliosis | D012600 | EFO_0004273 | M41 | 1 | — | — | — | — | 1 |
| Sleep initiation and maintenance disorders | D007319 | F51.01 | 1 | — | — | — | — | 1 | |
| Dyssomnias | D020920 | 1 | — | — | — | — | 1 | ||
| Central auditory diseases | D001304 | 1 | — | — | — | — | 1 | ||
| Premature birth | D047928 | EFO_0003917 | O60 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative complications | D011183 | — | — | — | — | 4 | 4 | ||
| Inhalation anesthesia | D000769 | — | — | — | — | 4 | 4 | ||
| Liver transplantation | D016031 | EFO_0010682 | — | — | — | — | 3 | 3 | |
| Urologic diseases | D014570 | N39.9 | — | — | — | — | 3 | 3 | |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | — | — | — | 3 | 3 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 3 | 3 |
| Pituitary neoplasms | D010911 | — | — | — | — | 3 | 3 | ||
| Fertilization in vitro | D005307 | — | — | — | — | 2 | 2 | ||
| Operative surgical procedures | D013514 | — | — | — | — | 2 | 2 | ||
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PROPOFOL |
| INN | propofol |
| Description | Propofol is a phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group. It has a role as an intravenous anaesthetic, a sedative, a radical scavenger, an antiemetic and an anticonvulsant. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)c1cccc(C(C)C)c1O |
Target
Agency Approved
No data
Alternate
HCN1
HCN1
Organism
Homo sapiens
Gene name
HCN1
Gene synonyms
BCNG1
NCBI Gene ID
Protein name
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Protein synonyms
BCNG-1, Brain cyclic nucleotide-gated channel 1
Uniprot ID
Mouse ortholog
Hcn1 (15165)
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Q9D613)
Variants
Clinical Variant
No data
Financial
Diprivan - AstraZeneca
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 51,522 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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108,352 adverse events reported
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