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Propantheline bromide
Pro-banthine (propantheline bromide) is a small molecule pharmaceutical. Propantheline bromide was first approved as Pro-banthine on 1982-01-01. It is used to treat irritable bowel syndrome, pancreatitis, peptic ulcer, spasm, and urethral diseases amongst others in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M1, muscarinic acetylcholine receptor M2, and muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M4.
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Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
nervous system diseasesD009422
urogenital diseasesD000091642
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Propantheline bromide
Tradename
Company
Number
Date
Products
PRO-BANTHINEG.D. SearleN-008843 DISCN1982-01-01
1 products
PRO-BANTHINEShireN-008732 DISCN1982-01-01
2 products, RLD
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
irritable bowel syndromeEFO_0000555D043183K58
pancreatitisEFO_0000278D010195K85
peptic ulcerHP_0004398D010437K27
spasm—D013035M62.83
urethral diseases—D014522N36.9
urinary bladder diseases—D001745N32.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Urinary calculiD014545N20.9———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Overactive urinary bladderD053201EFO_1000781N32.811————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePROPANTHELINE BROMIDE
INNpropantheline bromide
Description
Propantheline bromide is a member of xanthenes.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc2ccccc21)C(C)C.[Br-]
Identifiers
PDB—
CAS-ID50-34-0
RxCUI8762
ChEMBL IDCHEMBL1240
ChEBI ID—
PubChem CID9279
DrugBankDBSALT000225
UNII IDUX9Z118X9F (ChemIDplus, GSRS)
Target
Agency Approved
CHRM1
CHRM1
CHRM2
CHRM2
CHRM3
CHRM3
Organism
Homo sapiens
Gene name
CHRM1
Gene synonyms
NCBI Gene ID
1128
Protein name
muscarinic acetylcholine receptor M1
Protein synonyms
acetylcholine receptor, muscarinic 1
Uniprot ID
Q96RH1
Mouse ortholog
Chrm1 (12669)
muscarinic acetylcholine receptor M1 (Q8BJN3)
Alternate
CHRM4
CHRM4
Organism
Homo sapiens
Gene name
CHRM4
Gene synonyms
NCBI Gene ID
1132
Protein name
muscarinic acetylcholine receptor M4
Protein synonyms
acetylcholine receptor, muscarinic 4
Uniprot ID
Q4VBK7
Mouse ortholog
Chrm4 (12672)
muscarinic acetylcholine receptor M4 (Q64056)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 519 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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41 adverse events reported
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