Chloroguanide
Chloroguanide is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Therapeutic Areas
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Trade Name
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EMA
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atovaquone and proguanil hydrochloride | ANDA | 2023-03-27 |
Indications
FDA
EMA
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Agency Specific
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
453 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infertility | D007246 | EFO_0000545 | 3 | 4 | 9 | 28 | 29 | 72 | |
| Premature birth | D047928 | EFO_0003917 | O60 | — | 9 | 19 | 5 | 14 | 40 |
| Female infertility | D007247 | EFO_0008560 | N97 | — | — | 3 | 6 | 11 | 20 |
| Premature obstetric labor | D007752 | O60 | 2 | 4 | 2 | 7 | 6 | 20 | |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 4 | 1 | 1 | 3 | 11 | 19 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 2 | — | 3 | 4 | 8 | 17 |
| Menopause | D008593 | EFO_0003922 | N95 | 1 | 5 | 4 | 6 | 2 | 17 |
| Fertilization in vitro | D005307 | — | — | 4 | 2 | 8 | 14 | ||
| Contraception | D003267 | — | 1 | — | 4 | 5 | 10 | ||
| Tobacco use disorder | D014029 | F17 | 1 | 3 | — | 1 | 5 | 10 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary disease | D003327 | — | — | 5 | — | 1 | 6 | ||
| Hot flashes | D019584 | — | — | 3 | — | 2 | 5 | ||
| Endometrial neoplasms | D016889 | EFO_0004230 | 1 | 4 | 1 | — | — | 5 | |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 5 | — | — | 5 |
| Cocaine-related disorders | D019970 | F14 | 1 | 1 | 1 | — | 3 | 5 | |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | 4 | — | — | 4 |
| Leiomyoma | D007889 | HP_0000131 | D25 | — | 1 | 2 | — | — | 3 |
| Endometriosis | D004715 | EFO_0001065 | N80 | — | — | 1 | — | 2 | 3 |
| Traumatic brain injuries | D000070642 | S06 | 2 | 1 | 1 | — | — | 3 | |
| Anorexia nervosa | D000856 | EFO_0004215 | F50.0 | — | 2 | 2 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | 2 | — | — | 1 | 3 |
| Placenta previa | D010923 | EFO_0007442 | O44 | — | 1 | — | — | 1 | 2 |
| Covid-19 | D000086382 | U07.1 | 1 | 1 | — | — | — | 2 | |
| Ovulation induction | D010062 | — | 1 | — | — | — | 1 | ||
| Orthostatic intolerance | D054971 | — | 1 | — | — | — | 1 | ||
| Aging | D000375 | GO_0007568 | R41.81 | 1 | 1 | — | — | — | 1 |
| Mania | D000087122 | F30 | — | 1 | — | — | — | 1 | |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 1 | — | — | — | 1 |
| Bulimia nervosa | D052018 | EFO_0005204 | F50.2 | — | 1 | — | — | — | 1 |
| Feeding and eating disorders | D001068 | F50 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperandrogenism | D017588 | 3 | — | — | — | 3 | 6 | ||
| Pharmacokinetics | D010599 | 4 | — | — | — | — | 4 | ||
| Menstruation disturbances | D008599 | HP_0400007 | N91.5 | 2 | — | — | — | — | 2 |
| Puberty | D011627 | EFO_0001382 | 2 | — | — | — | — | 2 | |
| Premenstrual syndrome | D011293 | N94.3 | 1 | — | — | — | — | 1 | |
| Estrogen replacement therapy | D015914 | 1 | — | — | — | — | 1 | ||
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | 1 | — | — | — | — | 1 | |
| Glioblastoma | D005909 | EFO_0000515 | 1 | — | — | — | — | 1 | |
| Gliosarcoma | D018316 | 1 | — | — | — | — | 1 | ||
| Sexual abstinence | D012746 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 2 | 2 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.81 | — | — | — | — | 2 | 2 |
| Tobacco use cessation | D020340 | — | — | — | — | 2 | 2 | ||
| Preimplantation diagnosis | D019836 | — | — | — | — | 1 | 1 | ||
| Eye abnormalities | D005124 | HP_0000478 | Q15.9 | — | — | — | — | 1 | 1 |
| Pregnancy outcome | D011256 | — | — | — | — | 1 | 1 | ||
| Reproductive behavior | D043762 | — | — | — | — | 1 | 1 | ||
| Circadian rhythm | D002940 | EFO_0004354 | — | — | — | — | 1 | 1 | |
| Anovulation | D000858 | — | — | — | — | 1 | 1 | ||
| Breast density | D000071060 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CHLOROGUANIDE |
| INN | proguanil |
| Description | Proguanil is a biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells. It has a role as an antimalarial, an antiprotozoal drug and an EC 1.5.1.3 (dihydrofolate reductase) inhibitor. It is a member of biguanides and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 500-92-5 |
| RxCUI | 2382 |
| ChEMBL ID | CHEMBL1377 |
| ChEBI ID | 8455 |
| PubChem CID | 6178111 |
| DrugBank | DB01131 |
| UNII ID | S61K3P7B2V (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
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Safety
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Adverse Events
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40,002 adverse events reported
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