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Procarbazine
Matulane (procarbazine) is a small molecule pharmaceutical. Procarbazine was first approved as Matulane on 1982-01-01. It is used to treat brain neoplasms, hodgkin disease, lung neoplasms, melanoma, and multiple myeloma amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
respiratory tract diseasesD012140
nervous system diseasesD009422
cardiovascular diseasesD002318
hemic and lymphatic diseasesD006425
immune system diseasesD007154
Trade Name
FDA
EMA
Matulane
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Procarbazine hydrochloride
Tradename
Company
Number
Date
Products
MATULANELeadiant BiosciencesN-016785 RX1982-01-01
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
matulaneNew Drug Application2020-11-19
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
brain neoplasmsEFO_0003833D001932C71
hodgkin diseaseD006689C81
lung neoplasmsD008175C34.90
melanomaD008545
multiple myelomaD009101C90.0
non-hodgkin lymphomaD008228C85.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
L01: Antineoplastic agents
L01X: Other antineoplastic agents in atc
L01XB: Methylhydrazines, antineoplastics
L01XB01: Procarbazine
HCPCS
Code
Description
S0182
Procarbazine hydrochloride, oral, 50 mg
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePROCARBAZINE
INNprocarbazine
Description
Procarbazine is a benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands. It has a role as an antineoplastic agent. It is a member of hydrazines and a member of benzamides. It is a conjugate base of a procarbazine(1+).
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CNNCc1ccc(C(=O)NC(C)C)cc1
Identifiers
PDB
CAS-ID671-16-9
RxCUI8702
ChEMBL IDCHEMBL1321
ChEBI ID71417
PubChem CID4915
DrugBankDB01168
UNII ID35S93Y190K (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Safety
Black-box Warning
Black-box warning for: Matulane
Adverse Events
Top Adverse Reactions
0 adverse events reported
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