Probucol
Lorelco (probucol) is a small molecule pharmaceutical. Probucol was first approved as Lorelco on 1982-01-01. It is used to treat coronary artery disease, hypercholesterolemia, and hyperlipoproteinemias in the USA. The pharmaceutical is active against phospholipid-transporting ATPase ABCA1.
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Commercial
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Probucol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LORELCO | Sanofi | N-017535 DISCN | 1982-01-01 | 2 products |
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| coronary artery disease | — | D003324 | I25.1 |
| hypercholesterolemia | HP_0003124 | D006937 | — |
| hyperlipoproteinemias | — | D006951 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
54 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 1 | — | 1 | 5 | 8 |
| Cytomegalovirus retinitis | D017726 | EFO_1001302 | 1 | 1 | — | 1 | 2 | 5 | |
| Drug interactions | D004347 | 2 | — | — | 1 | — | 3 | ||
| Human influenza | D007251 | EFO_0007328 | J11.1 | — | — | — | 1 | — | 1 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | 3 | — | 1 | 4 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | 1 | — | — | 3 |
| Blood pressure | D001794 | EFO_0004325 | — | — | 1 | — | — | 1 | |
| Overweight | D050177 | E66.3 | — | — | 1 | — | — | 1 | |
| Intraabdominal infections | D059413 | — | — | 1 | — | — | 1 | ||
| Heart failure | D006333 | EFO_0003144 | I50 | — | 1 | 1 | — | — | 1 |
| Cystitis | D003556 | EFO_1000025 | N30 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial infections | D001424 | A49 | 1 | 1 | — | — | 1 | 2 | |
| Prehypertension | D058246 | — | 1 | — | — | — | 1 | ||
| Hyperuricemia | D033461 | — | 1 | — | — | — | 1 | ||
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | 1 | — | — | — | 1 |
| Traumatic brain injuries | D000070642 | S06 | 1 | 1 | — | — | — | 1 | |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | — | 1 | — | — | — | 1 |
| Substance withdrawal syndrome | D013375 | EFO_0005800 | — | 1 | — | — | — | 1 | |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 1 | — | — | — | 1 |
| Chronic pain | D059350 | HP_0012532 | — | 1 | — | — | — | 1 | |
| Covid-19 | D000086382 | U07.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 9 | — | — | — | — | 9 | ||
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 3 | — | — | — | — | 3 |
| Pharmacokinetics | D010599 | 1 | — | — | — | — | 1 | ||
| Cytomegalovirus infections | D003586 | EFO_0001062 | B25 | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | C80 | 1 | — | — | — | — | 1 | |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 1 | — | — | — | — | 1 |
| Chondrocalcinosis | D002805 | HP_0000934 | M11.2 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Progressive multifocal leukoencephalopathy | D007968 | EFO_0007455 | A81.2 | — | — | — | — | 1 | 1 |
| Gout | D006073 | EFO_0004274 | M10 | — | — | — | — | 1 | 1 |
| Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | — | — | — | — | 1 | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 1 | 1 |
| Ear diseases | D004427 | EFO_1001455 | H93.9 | — | — | — | — | 1 | 1 |
| Renal elimination | D065667 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PROBUCOL |
| INN | probucol |
| Description | Probucol is a dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood. It has a role as an anticholesteremic drug, an antioxidant, an anti-inflammatory drug, a cardiovascular drug and an antilipemic drug. It is a dithioketal and a polyphenol. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1 |
Identifiers
| PDB | — |
| CAS-ID | 23288-49-5 |
| RxCUI | 8699 |
| ChEMBL ID | CHEMBL608 |
| ChEBI ID | 8427 |
| PubChem CID | 4912 |
| DrugBank | DB01599 |
| UNII ID | P3CTH044XJ (ChemIDplus, GSRS) |
Target
Agency Approved
ABCA1
ABCA1
Organism
Homo sapiens
Gene name
ABCA1
Gene synonyms
ABC1, CERP
NCBI Gene ID
Protein name
phospholipid-transporting ATPase ABCA1
Protein synonyms
ABC-1, ATP-binding cassette 1, ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter 1, ATP-binding cassette transporter A1, ATP-binding cassette, sub-family A (ABC1), member 1, Cholesterol efflux regulatory protein, membrane-bound
Uniprot ID
Mouse ortholog
Abca1 (11303)
phospholipid-transporting ATPase ABCA1 (P41233)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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223 adverse events reported
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